What is a Loading Dose?
September 10, 2025 Understanding how drugs reach steady-state levels is essential for safe and effective…
CertaraSeptember 10, 2025
Extrapolating AUC to Infinity
AUC calculations are simple but nuanced. In this blog, we look at how to extrapolate…
CertaraMay 15, 2025
Calculating AUC (Linear and Log-linear)
AUC calculations are simple but nuanced. In this blog, we look at how to calculate…
CertaraApril 2, 2025
Accumulation: What It Means and How to Calculate It
Watch our on demand webinar to discover fast, flexible, frictionless PK/PD workflows with Phoenix Cloud.…
CertaraApril 2, 2025
9 Frequently Misunderstood Concepts in PK/PD Modeling
In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…
CertaraNovember 3, 2015
9 Things Your Boss Wishes You Knew About PK/PD Modeling
Over the course of my career, I have taught the theory and practical applications of PK/PD…
CertaraSeptember 15, 2015
Derivation for Logarithmic Trapezoidal AUC Calculation
Calculating area under the curve requires the use of two separate equations: one is follows…
CertaraAugust 5, 2015
Calculating the Elimination Rate Constant
The elimination rate constant is the rate at which drug is cleared from the body…
CertaraFebruary 2, 2015
Adding a Placebo Component to Your PK/PD Model in Phoenix
PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…
CertaraAugust 20, 2014
Bioanalytical Calibration Curves
At the request of a reader, I have decided to extend my series on bioanalysis…
CertaraAugust 12, 2014
