Knowledge Base Archives

Blog Knowledge Base

Trial Designs: Non-inferiority vs. Superiority vs. Equivalence

Understand superiority, non-inferiority, and equivalence trials, how their hypotheses differ, and how trial design impacts…

CertaraFebruary 3, 2026

Blog Knowledge Base

What is a Loading Dose?

Learn what a loading dose is, why it's vital for reaching therapeutic drug levels swiftly,…

CertaraSeptember 10, 2025

Blog Knowledge Base

Extrapolating AUC to Infinity

AUC calculations are simple but nuanced. In this blog, we look at how to extrapolate…

CertaraMay 15, 2025

Blog Knowledge Base

Calculating AUC (Linear and Log-linear)

AUC calculations are simple but nuanced. In this blog, we look at how to calculate…

CertaraApril 2, 2025

Blog Knowledge Base

Accumulation: What It Means and How to Calculate It

In this blog, we look closely at drug accumulation ratio, to help you understand and…

CertaraApril 2, 2025

Knowledge Base

9 Frequently Misunderstood Concepts in PK/PD Modeling

In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…

CertaraNovember 3, 2015

Knowledge Base

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Over the course of my career, I have taught the theory and practical applications of PK/PD…

CertaraSeptember 15, 2015

Knowledge Base

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating area under the curve requires the use of two separate equations: one is follows…

CertaraAugust 5, 2015

Blog Knowledge Base

Calculating the Elimination Rate Constant

The elimination rate constant is the rate at which drug is cleared from the body…

CertaraFebruary 2, 2015

Knowledge Base

Adding a Placebo Component to Your PK/PD Model in Phoenix

PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…

CertaraAugust 20, 2014

Knowledge Base

Trial Designs: Non-inferiority vs. Superiority vs. Equivalence

What is a Loading Dose?

Extrapolating AUC to Infinity

Calculating AUC (Linear and Log-linear)

Accumulation: What It Means and How to Calculate It

9 Frequently Misunderstood Concepts in PK/PD Modeling

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Derivation for Logarithmic Trapezoidal AUC Calculation

Calculating the Elimination Rate Constant

Adding a Placebo Component to Your PK/PD Model in Phoenix

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