Knowledge Base Archives

Blog Knowledge Base

Where Did the 80-125% Bioequivalence Criteria Come From?

Discover what bioequivalence criteria mean, why the 80-125% bioequivalence range is used, and how custom…

CertaraMarch 27, 2026

Blog Knowledge Base

What is GLP (Good Laboratory Practice)?

Read this blog to understand GLP (Good Laboratory Practice) and associated QA audits, and proper…

CertaraMarch 18, 2026

Blog Knowledge Base

Understanding and Calculating Steady State Pharmacokinetics

Steady state pharmacokinetics can seem abstract and confusing. Read this blog to gain a better…

CertaraMarch 5, 2026

Blog Knowledge Base

Trial Designs: Non-inferiority vs. Superiority vs. Equivalence

Understand superiority, non-inferiority, and equivalence trials, how their hypotheses differ, and how trial design impacts…

CertaraFebruary 3, 2026

Blog Knowledge Base

What is a Loading Dose?

Learn what a loading dose is, why it's vital for reaching therapeutic drug levels swiftly,…

CertaraSeptember 10, 2025

Blog Knowledge Base

Extrapolating AUC to Infinity

AUC calculations are simple but nuanced. In this blog, we look at how to extrapolate…

CertaraMay 15, 2025

Blog Knowledge Base

Calculating AUC (Linear and Log-linear)

AUC calculations are simple but nuanced. In this blog, we look at how to calculate…

CertaraApril 2, 2025

Blog Knowledge Base

Accumulation: What It Means and How to Calculate It

In this blog, we look closely at drug accumulation ratio, to help you understand and…

CertaraApril 2, 2025

Knowledge Base

9 Frequently Misunderstood Concepts in PK/PD Modeling

In teaching pharmacometrics, I've noticed that scientists have difficulty with certain PK/PD modeling concepts. Maybe…

CertaraNovember 3, 2015

Knowledge Base

9 Things Your Boss Wishes You Knew About PK/PD Modeling

Over the course of my career, I have taught the theory and practical applications of PK/PD…

CertaraSeptember 15, 2015

Knowledge Base

Where Did the 80-125% Bioequivalence Criteria Come From?

What is GLP (Good Laboratory Practice)?

Understanding and Calculating Steady State Pharmacokinetics

Trial Designs: Non-inferiority vs. Superiority vs. Equivalence

What is a Loading Dose?

Extrapolating AUC to Infinity

Calculating AUC (Linear and Log-linear)

Accumulation: What It Means and How to Calculate It

9 Frequently Misunderstood Concepts in PK/PD Modeling

9 Things Your Boss Wishes You Knew About PK/PD Modeling

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