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A glimpse into the future of model-informed drug discovery and development
A glimpse into the future of model-informed drug discovery and development

A glimpse into the future of model-informed drug discovery and development

Explore the future of Model-Informed Drug Development (MIDD), including advances in pharmacometrics, PBPK, QSP, precision dosing, AI, and regulatory science.

Latest publications

Popular publications

Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate
Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate

Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate

Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data
Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data

Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data

Current State-of-the-Art and Future Advancements of Model-Based Meta-Analysis
Current State-of-the-Art and Future Advancements of Model-Based Meta-Analysis

Current State-of-the-Art and Future Advancements of Model-Based Meta-Analysis

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients
Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment
Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment

Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment

Oxford Academic, Neuro-Oncology Pediatrics – BRAF pub: Growth recovery in patients with BRAF-altered pediatric low-grade glioma following treatment with tovorafenib
Oxford Academic, Neuro-Oncology Pediatrics – BRAF pub: Growth recovery in patients with BRAF-altered pediatric low-grade glioma following treatment with tovorafenib

Oxford Academic, Neuro-Oncology Pediatrics – BRAF pub: Growth recovery in patients with BRAF-altered pediatric low-grade glioma following treatment with tovorafenib

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Simcyp Publications and Independent Applications

We are proud to share our publications by the Simcyp R&D Team (1997 – Present) and independent applications of Simcyp by industry, academia, and regulatory organizations (2007 – Present).

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A glimpse into the future of model-informed drug discovery and development

Publication Certara Services Clinical Pharmacology Clinical Trials Drug Development Drug Safety Drug-Drug Interactions (DDI) Model Informed Drug Development Modeling and Simulation Modeling and Simulation - PBPK Modeling and Simulation - PK/PD Modeling and Simulation - QSP Oncology/Hematology Pharmacometrics Therapeutic Specialties

Refinement of Operating Characteristics for Model-Based TGI Metrics Decision Support to Ungate a Pivotal Trial in Oncology

Publication Certara Services Clinical Pharmacology Clinical Trials Drug Development Model Informed Drug Development Modeling and Simulation Modeling and Simulation - PK/PD Oncology/Hematology Pharmacometrics Therapeutic Specialties

Model-Informed Decision Making from Drug Discovery to Reimbursement: A Roadmap for Clinical Pharmacology in Value-Based Healthcare

Publication

Advances and Challenges in Model-Informed Precision Dosing of Antimicrobials for Pediatric Patients

Publication Certara Services Clinical Pharmacology Drug Development Infectious Disease Model Informed Drug Development Modeling and Simulation Modeling and Simulation - PK/PD

Conditional activation of IL-12 through a Fibronectin-EDB dependent switch gate

Publication Biologics Modeling and Simulation Modeling and Simulation - QSP

Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data

Publication Biologics Certara Products - Certara IQ Modeling and Simulation Modeling and Simulation - QSP

Current State-of-the-Art and Future Advancements of Model-Based Meta-Analysis

Publication Clinical Pharmacology Clinical Trials Drug Development Model Informed Drug Development Modeling and Simulation Modeling and Simulation - PK/PD Modeling and Simulation - QSP

Clinical Validation of a QSP Model for ISB 2001, a Trispecific T Cell Engager to Support Optimal FIH Study Design in RRMM Patients

Publication Biologics Modeling and Simulation Modeling and Simulation - QSP

Review: application and opportunities for machine learning and artificial intelligence in preclinical immunogenicity risk assessment

Publication Biologics Certara Products - Certara IQ Modeling and Simulation - QSP
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