PK/PD Modeling & Simulation

Changing Column Names and Units in Phoenix WinNonlin

Nathan Teuscher

One of the most common tasks when working with data in Phoenix WinNonlin is to change the column titles or units. In many software packages that consists of clicking on the data spreadsheet and re-typing the new information; however, with Phoenix, you have to take a few additional steps. Here’s some quick tips on how […]

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Topics: PK/PD Modeling & Simulation

How to Filter Data with Phoenix WinNonlin

Nathan Teuscher

Phoenix WinNonlin is Certara’s new implementation of the popular pharmacokinetic software that has been the mainstay of non-compartmental analysis for over 15 years. But, this newest version is the biggest change in the software since the original PC Nonlin was converted to the Windows-based “WinNonlin” (i.e. Windows Nonlin). In Phoenix WinNonlin, there are a powerful […]

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Topics: PK/PD Modeling & Simulation

Calculating Urine PK Parameters

Nathan Teuscher

Pharmacokinetic analysis normally focuses on systemic exposure to a drug; however, much can be learned from urinary pharmacokinetic parameters. Urinary PK parameters tell you about how much drug was absorbed (at a minimum), and how much drug is eliminated through the kidney. Often it provides easy access to metabolites that are also eliminated in the urine. […]

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Topics: PK/PD Modeling & Simulation

What Can We Learn from a Human Mass Balance Study?

Nathan Teuscher

Mass balance studies are also called “C-14 studies” or “Absorption, Metabolism, and Excretion (AME) studies”. It is important to understand what you are trying to learn from the experiment. The primary objectives of a mass balance study are generally: To determine the mass balance of drug-related material following dose administration To determine the ratio of […]

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Topics: PK/PD Modeling & Simulation

Accumulation: What It Means and How to Calculate It

Nathan Teuscher

A reader, Michael, asked me to discuss the concept of accumulation. This term is used frequently in both the nonclinical and clinical setting. Some people use the word with fear, while others explain it in complicated terms. Accumulation represents the relationship between the dosing interval and the rate of elimination for the drug. When the […]

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Topics: PK/PD Modeling & Simulation

Bioavailability

Nathan Teuscher

The term bioavailability is used very frequently in pharmacokinetic discussions. Often it is misused and complicated by those who don’t understand its meaning. Bioavailability simply means the fraction of administered drug that reached the systemic circulation (blood). It can range from 0% (no drug) to 100% (all of the administered drug). Absolute vs Relative The […]

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Topics: PK/PD Modeling & Simulation

Designing a Clinical Drug-drug Interaction Study

Nathan Teuscher

After a much longer delay that I expected, I am back to blogging on a regular basis. Today I want to discuss a common topic among clinical pharmacologists. How do you properly design a drug-drug interaction study? Defining drug-drug interactions While these studies may appear complicated, they can be simplified very quickly to make the […]

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Topics: PK/PD Modeling & Simulation
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