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User-friendly and powerful nonlinear mixed effect modeling software

Phoenix NLMETM lets you focus on your models, not the tools required to implement the models.   Phoenix NLME is a population modeling and simulation software for scientists with varying levels of experience—from novice PK/PD scientists to the most advanced modelers. This comprehensive package includes integrated data preparation, modeling, and graphics tools with the same user interface that is used in Phoenix WinNonlin™.

18 of the top 20 pharmaceutical companies in the world use Phoenix NLME.


Accomplish more with the latest release of the Phoenix platform with:

  • Open-source plotting (RShiny ggquickEDA)
  • Built-in plot and Reporter upgrades
  • Phoenix NLME: Additional Visual Predictive Check features
  • Phoenix NLME: Phoenix Modeling Language updates (Distributed delay function)


Widely used for regulatory submissions

Phoenix NLME meets all scientific and technical requirements for PK/PD analyses. Because of its flexibility and power, Phoenix NLME is used across drug development phases and for global regulatory submissions, including:

  • Translational modeling
  • Extrapolation of PK data from animals to humans
  • Prediction of the pharmacodynamics in humans based on in vitro models
  • Combination of PK and PD data from multiple animal studies
  • Enhancement of study designs to minimize animal use
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Widely used for regulatory submissions
Grid computing and algorithms for faster results

Grid computing and algorithms for faster results

  • Includes QRPEM, the fastest expectation maximization algorithm available 
  • Comes grid-enabled with an algorithm that uses the maximum number of cores for each run to minimize time from days to minutes. Send jobs to a remote computing platform with one click.
  • Offers separates analyses for different types of data such as continuous data with BQLs, categorical data, and time to event data with Visual Predictive Check
  • Simplifies coding delays in PK/PD models with the distributed delay function, which can be used in place of transit compartments, dual absorption models, effect compartment models, and indirect response models.
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Intuitive graphical user interface

  • Develop models without coding with our graphical model editor and model library. Advanced users can code using Phoenix Modeling Language (PML)
  • Avoid poor parameterization with the graphical tool for initial model parameter estimates 
  • Quickly troubleshoot issues with diagnostic dialog messages that pinpoint errors
  • Compare models side-by-side with the comparer tool
  • Automatically generate diagnostic outputs for each model to assess model robustness
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Intuitive graphical user interface