Therapeutic Specialties Archives

Publication

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

CertaraSeptember 1, 2007

Publication

The Problems in Scaling Adult Drug Doses to Children

Many drugs are unlicensed in children and consequently their doses have been scaled down from…

CertaraMarch 15, 2007

Publication

Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor

The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…

CertaraMarch 1, 2007

Publication

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

The aim of this study was to model the in vivo kinetic consequences of mechanism-based…

CertaraNovember 1, 2006

Publication

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…

CertaraSeptember 1, 2006

Publication

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…

CertaraMay 1, 2006

Publication

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

The aim of this study was to develop a pain relief model for a cyclooxygenase…

CertaraApril 1, 2006

Publication

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

A diversity of equations is available for the estimation of liver volume (LV), derived from…

CertaraDecember 1, 2005

Publication

Model-based Development of Gemcabene, a New Lipid-altering Agent

The purpose of this study was to evaluate the value of model-based, quantitative decision making…

CertaraOctober 7, 2005

Publication

Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model

Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…

CertaraSeptember 1, 2005

Therapeutic Specialties

Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems

The Problems in Scaling Adult Drug Doses to Children

Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor

Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA

Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates

Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor

Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation

Changes in Liver Volume from Birth to Adulthood: A Meta-analysis

Model-based Development of Gemcabene, a New Lipid-altering Agent

Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model

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