Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems Publication Inactivation of CYP2D6 by Methylenedioxymethamphetamine in Different Recombinant Expression Systems Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…CertaraSeptember 1, 2007
The Problems in Scaling Adult Drug Doses to Children Publication The Problems in Scaling Adult Drug Doses to Children Many drugs are unlicensed in children and consequently their doses have been scaled down from…CertaraMarch 15, 2007
Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor Publication Predictive Population Pharmacokinetic/Pharmacodynamic Model for a Novel COX-2 Inhibitor The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…CertaraMarch 1, 2007
Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA Publication Implications of Mechanism-based Inhibition of CYP2D6 for the Pharmacokinetics and Toxicity of MDMA The aim of this study was to model the in vivo kinetic consequences of mechanism-based…CertaraNovember 1, 2006
Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates Publication Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…CertaraSeptember 1, 2006
Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor Publication Development of a Predictive Pharmacokinetic Model for a Novel Cyclooxygenase-2 Inhibitor A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…CertaraMay 1, 2006
Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation Publication Enriched Analgesic Efficacy Studies: An Assessment by Clinical Trial Simulation The aim of this study was to develop a pain relief model for a cyclooxygenase…CertaraApril 1, 2006
Changes in Liver Volume from Birth to Adulthood: A Meta-analysis Publication Changes in Liver Volume from Birth to Adulthood: A Meta-analysis A diversity of equations is available for the estimation of liver volume (LV), derived from…CertaraDecember 1, 2005
Model-based Development of Gemcabene, a New Lipid-altering Agent Publication Model-based Development of Gemcabene, a New Lipid-altering Agent The purpose of this study was to evaluate the value of model-based, quantitative decision making…CertaraOctober 7, 2005
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Publication Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…CertaraSeptember 1, 2005