Publication

Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate in Chinese Subjects with and without Hemodialysis-Dependent Stage 5 Chronic Kidney Disease

Discover how evaluated ferric pyrophosphate citrate pharmacokinetics and safety in healthy and hemodialysis‑dependent CKD patients…

CertaraApril 5, 2022

Publication

Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms

Explore how CYP2C9 and OATP1B1 genetic effects on torsemide PK in healthy Korean males, supporting…

CertaraApril 1, 2022

Publication

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

Find out how voriconazole more than doubles ruxolitinib exposure, supporting dose adjustment guidance for hematologic…

CertaraMarch 25, 2022

Publication

Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice

See how major PK and metabolic differences between primaquine enantiomers, informing safer and more effective…

CertaraFebruary 5, 2022

Publication

Bioequivalence and Safety Assessment of Two Formulations of Metformin Hydrochloride Sustained-Release Tablets (Yuantang® SR and Glucophage® XR) Under Fed Conditions in Healthy Chinese Adult Subjects: An Open-Label, Two-Way Crossover, Sequence Randomized Phase I Clinical Trial

Learn how the confirmed bioequivalence of metformin SR formulations under fed conditions, with matched PK…

CertaraJanuary 21, 2022

Publication

The effect of nutritional status on the pharmacokinetic profile of acetaminophen+A124:N124

Explore how nutritional status strongly alters acetaminophen PK at toxic doses, with low‑protein diets producing…

CertaraJanuary 20, 2022

Publication

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Discover how major CYP2C19 genotype effects on voriconazole PK, supporting genotype‑guided dose adjustments to avoid…

CertaraJanuary 3, 2022

Publication

The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers

See how rifampicin reduces fuzuloparib exposure by up to 90%, confirming a major CYP3A4 induction…

CertaraDecember 26, 2021

Publication

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma

Find out how lower vinorelbine exposure in children and strong BSA effects, supporting dose refinement…

CertaraDecember 13, 2021

Publication

Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections

Learn how adjusted‑body‑weight dosing optimises polymyxin B exposure in obese patients, avoiding toxicity while achieving…

CertaraNovember 22, 2021

Certara Products – Phoenix

Pharmacokinetics and Safety of Ferric Pyrophosphate Citrate in Chinese Subjects with and without Hemodialysis-Dependent Stage 5 Chronic Kidney Disease

Population Pharmacokinetic (Pop-PK) Analysis of Torsemide in Healthy Korean Males Considering CYP2C9 and OATP1B1 Genetic Polymorphisms

Co-Administration with Voriconazole Doubles the Exposure of Ruxolitinib in Patients with Hematological Malignancies

Comparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice

Bioequivalence and Safety Assessment of Two Formulations of Metformin Hydrochloride Sustained-Release Tablets (Yuantang® SR and Glucophage® XR) Under Fed Conditions in Healthy Chinese Adult Subjects: An Open-Label, Two-Way Crossover, Sequence Randomized Phase I Clinical Trial

The effect of nutritional status on the pharmacokinetic profile of acetaminophen+A124:N124

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma

Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections

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