Publication: Toxicology and Applied Pharmacology
Abstract
Nutritional imbalance is common worldwide and can alter drug pharmacokinetics, but its effect on acetaminophen exposure at toxic doses across different dietary patterns had not been well characterized. This study compared the pharmacokinetic profile of a toxic acetaminophen dose in female mice fed normal, low-protein, or high-fat diets for 15 weeks, using non-compartmental analysis in Phoenix WinNonlin. The low-protein diet group showed the highest acetaminophen exposure (Cmax and AUC), followed by the normal diet and then the high-fat diet group. These findings indicate that nutritional status meaningfully alters acetaminophen pharmacokinetics at toxic doses, suggesting relevance for hepatotoxicity risk assessment across differing dietary patterns.
Author(s): Souza VD, Shetty M, Badanthadka M, Mamatha BS, Vijayanarayana K
Published: January 20, 2022
Phoenix WinNonlin: Diet-Dependent Toxicity Risk
Phoenix WinNonlin’s non-compartmental analysis showed nutritional status meaningfully shifts toxic-dose acetaminophen exposure in this study. As part of a Phoenix platform cited in more than 33,000 peer-reviewed articles, Phoenix WinNonlin can be paired with AI PK Reports to turn an analysis into a complete PK document in minutes rather than days.
