Publication

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction.

Find out how Liver dysfunction increases nalbuphine half‑life and Vd; PK analysed using Phoenix WinNonlin.

CertaraJuly 26, 2022

Publication

Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real-World Patients

Explore how model predicts population‑level target attainment but large individual variability using Phoenix NLME.

CertaraJuly 25, 2022

Publication

Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single-center, open-label phase I trial.

Discover how itraconazole markedly increases SHR2554 exposure; PK interaction assessed using Phoenix WinNonlin.

CertaraJuly 16, 2022

Publication

CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.

See how CYP2A6 affects exposure; GABRA2 predicts heart‑rate abnormalities using Phoenix NLME.

CertaraJuly 7, 2022

Publication

A study to explore the appropriateness of dosing regimen of vancomycin in critically ill patients in a tertiary care unit of India

Learn how weight and creatinine clearance improve prediction; standard dosing insufficient using Phoenix NLME.

CertaraJune 30, 2022

Publication

Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers.

Find out how co‑administration shows BE‑range PK for both drugs using Phoenix WinNonlin.

CertaraJune 28, 2022

Publication

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.

Explore how brand and generics show similar exposure but different absorption timing using Phoenix NLME.

CertaraMay 21, 2022

Publication

Comparative clinical study of the pharmacokinetics and bioequivalence of the combined drug Mioreol and the combined use of mono-drugs containing donepezil and memantine

Discover how linear PK up to 600 mg; saturation at 800 mg; PK modelled using…

CertaraMay 13, 2022

Publication

Population PK of polymyxin B in critically ill patients receiving continuous venovenous haemofiltration

See how CVVH reduces AUC three‑fold; simulations support 200 mg load + 150 mg q12h…

CertaraMay 5, 2022

Publication

Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

See how uncovered large inter‑individual variability in CBD pharmacokinetics, showing 3.6‑fold exposure differences and long…

CertaraApril 19, 2022

Certara Products – Phoenix

Pharmacokinetic Study of Nalbuphine in Surgical Patients Undergoing General Anesthesia with Varying Degrees of Liver Dysfunction.

Leveraging a Previously Published Population Pharmacokinetic Model to Predict Rivaroxaban Exposure in Real-World Patients

Study on pharmacokinetic interactions between SHR2554 and itraconazole in healthy subjects: A single-center, open-label phase I trial.

CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.

A study to explore the appropriateness of dosing regimen of vancomycin in critically ill patients in a tertiary care unit of India

Evaluation of Pharmacokinetic Interactions Between the New SGLT2 Inhibitor SHR3824 and Valsartan in Healthy Chinese Volunteers.

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence.

Comparative clinical study of the pharmacokinetics and bioequivalence of the combined drug Mioreol and the combined use of mono-drugs containing donepezil and memantine

Population PK of polymyxin B in critically ill patients receiving continuous venovenous haemofiltration

Population Pharmacokinetics of Oral-Based Administration of Cannabidiol in Healthy Adults: Implications for Drug Development

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