Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma Publication Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma Find out how lower vinorelbine exposure in children and strong BSA effects, supporting dose refinement…CertaraDecember 13, 2021
Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections Publication Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections Learn how adjusted‑body‑weight dosing optimises polymyxin B exposure in obese patients, avoiding toxicity while achieving…CertaraNovember 22, 2021
A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats Publication A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats Explore how altered PK of fenugreek bioactives in diabetic rats, with faster absorption and slower…CertaraNovember 16, 2021
Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects Publication Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects Discover how bioequivalence of generic and branded budesonide nasal sprays, with matched PK and strong…CertaraNovember 16, 2021
Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients Publication Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients See how standard vancomycin dosing is insufficient for pediatric liver‑transplant patients, requiring higher or more…CertaraOctober 6, 2021
Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals Publication Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals Find out how body‑weight and sex effects on DEC PK in filariasis patients, supporting improved…CertaraJuly 26, 2021
Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis Publication Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis Learn how cystatin‑C improves vancomycin clearance prediction in PICS patients, reducing variability and preventing supratherapeutic…CertaraMarch 16, 2021
Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients Publication Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients Explore how key covariates and showed higher‑frequency dosing improves linezolid target attainment in critically ill…CertaraFebruary 8, 2021
Application of PK/PD modeling and simulation in drug discovery and development in China Blog Application of PK/PD modeling and simulation in drug discovery and development in China By Yuancheng Chen, Research Associate of Phase 1 Unit, Huashan Hospital, Fudan University, and visiting…CertaraAugust 7, 2020
Conventional & mechanistic IVIVC: Complementary or clashing methods? Blog Conventional & mechanistic IVIVC: Complementary or clashing methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…CertaraFebruary 9, 2016