A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats Publication A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats Explore how altered PK of fenugreek bioactives in diabetic rats, with faster absorption and slower…CertaraNovember 16, 2021
Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects Publication Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects Discover how bioequivalence of generic and branded budesonide nasal sprays, with matched PK and strong…CertaraNovember 16, 2021
Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients Publication Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients See how standard vancomycin dosing is insufficient for pediatric liver‑transplant patients, requiring higher or more…CertaraOctober 6, 2021
Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals Publication Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals Find out how body‑weight and sex effects on DEC PK in filariasis patients, supporting improved…CertaraJuly 26, 2021
Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis Publication Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis Learn how cystatin‑C improves vancomycin clearance prediction in PICS patients, reducing variability and preventing supratherapeutic…CertaraMarch 16, 2021
Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients Publication Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients Explore how key covariates and showed higher‑frequency dosing improves linezolid target attainment in critically ill…CertaraFebruary 8, 2021
Application of PK/PD modeling and simulation in drug discovery and development in China Blog Application of PK/PD modeling and simulation in drug discovery and development in China By Yuancheng Chen, Research Associate of Phase 1 Unit, Huashan Hospital, Fudan University, and visiting…CertaraAugust 7, 2020
Conventional & mechanistic IVIVC: Complementary or clashing methods? Blog Conventional & mechanistic IVIVC: Complementary or clashing methods? An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…CertaraFebruary 9, 2016
Common misconceptions about computer system validation Blog Common misconceptions about computer system validation January 28, 2015 Drug development professionals frequently use computer systems to help them understand the…CertaraJanuary 28, 2015
Using modeling and simulation to quantify the PK of an anti-HIV drug for babies Blog Using modeling and simulation to quantify the PK of an anti-HIV drug for babies As a scientist at Certara and proud Dad to my three kids, pediatric drug development…CertaraJanuary 15, 2015