Modeling and Simulation Archives

Publication

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

Madin–Darby canine kidney (MDCK) cells are widely used to study epithelial cell functionality. Their low…

CertaraJune 28, 2023

Case Study

Leveraging Pharmacokinetic Modeling & Scientific Communications Expertise Advances Sarcoidosis Drug Program

Certara's support, from dose optimization to medical writing, helps pharmaceutical companies advance their research, make…

CertaraJune 1, 2023

Case Study

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Bispecific antibodies are an emerging class of antibodies developed in recent years that provide new…

CertaraJanuary 23, 2023

Case Study

Simcyp Simulator Helps Optimize Drug Dosing in Adults & Adolescents with Orphan Disease

Congenital adrenal hyperplasia (CAH) affects about 400,000 patients worldwide. Current therapy for CAH uses a…

CertaraJune 6, 2022

Case Study

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Quetiapine is an atypical antipsychotic for treating schizophrenia, bipolar depression, bipolar mania that helps to…

CertaraAugust 26, 2021

Case Study

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

Aripiprazole lauroxil (Aristada®) was approved by the FDA for treating schizophrenia in adults in October…

CertaraAugust 12, 2021

Fact Sheet

Phoenix WinNonlin

CertaraJune 22, 2020

White Paper

Optimize Immuno-oncology Drug Discovery and Development Using QSP

A Quantitative Systems Pharmacology (QSP) approach for developing combination immune-oncology therapies can be used to…

CertaraJune 19, 2019

Brochure

Pirana Modeling Workbench

Pirana is a flexible and extendible modeling workbench with an intuitive graphical user interface for…

CertaraMay 28, 2019

Publication

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances

Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…

CertaraJuly 1, 2016

Modeling and Simulation

Interlaboratory Variability in the Madin–Darby Canine Kidney Cell Proteome

Leveraging Pharmacokinetic Modeling & Scientific Communications Expertise Advances Sarcoidosis Drug Program

Using Modeling & Simulation to Develop a Dosing Regimen for a Bispecific Antibody for Pediatric Cancer

Simcyp Simulator Helps Optimize Drug Dosing in Adults & Adolescents with Orphan Disease

Bridging Formulations of Quetiapine for Children with Schizophrenia or Bipolar Disorder

Aripiprazole lauroxil: PBPK for Dosing Regimen and DDI Identification

Phoenix WinNonlin

Optimize Immuno-oncology Drug Discovery and Development Using QSP

Pirana Modeling Workbench

More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances

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