With PopPK analysis now a standard requirement for regulatory submissions and expected by the FDA, scientists need flexible tools to streamline population PK/PD modeling. By integrating the Certara NLME engine directly into the R command line, RsNLME delivers unmatched flexibility and efficiency for pharmacometric workflows, and now connects to AI assistants through MCP for an even faster path from data to model.
Whether you’re a novice or an advanced user, RsNLME equips you with the software and resources to elevate your modeling capabilities, including educational guides, tutorials, and demonstration vignettes.
R Speaks NLME (RsNLME)
Open source flexibility for population PK/PD modeling
Learn more about R Speaks NLME (RsNLME)
Advanced population PK/PD modeling made simple
Enables flexible and seamless model workflow
Allows users to define models without in-depth knowledge of underlying code
Reduces time spent performing analyses
Connects your AI assistant directly to the NLME engine
Your AI assistant now speaks NLME
RsNLME connects to AI assistants through the Model Context Protocol (MCP), so your assistant can build, run, and diagnose NLME models directly using the Certara NLME engine. It follows established pharmacometric best practices at every step, from proposing a column mapping to planning a covariate search and producing goodness of fit and VPC diagnostics. You describe the modeling goal in plain language, and the assistant carries out the work, keeping you in control of every decision.
Connects to AI assistants through MCP for plain language model building
Fully compatible with Phoenix WinNonlin® and Phoenix® NLME models
Provides R tidyverse based syntax for streamlined model manipulation
How popPK modelers benefit
Open source flexibility
RsNLME works seamlessly with open-source R tools, offering users the choice between graphical and command-line interfaces for maximum flexibility.
Enhanced efficiency
Save valuable time on model translation and generate real-time configurable reports with RsNLME’s model results and VPCResults interfaces.
Educational resources
Take advantage of Certara University training tutorials, R package user guides, and other resources designed to support users of all skill levels at every step.
Why Certara
Certara empowers scientists with innovative tools and expertise to accelerate drug development and improve decision-making.
- Certara, a leader in biosimulation and modeling solutions, has made pharmacometrics a cornerstone of its expertise.
- Our modeling software is trusted by industry leaders and recognized by regulatory authorities as a reliable solution.
- Building on our proven AI capabilities, we continue to enhance our solutions across the drug development lifecycle, making them faster and more effective.
PK/PD Data Analysis, Concepts and Applications
Enhance your knowledge in PK analysis. Access comprehensive insights from distinguished experts in pharmacokinetics and pharmacodynamics.
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With RsNLME, your data is secure
Certara holds ISO 27001 certification for Certara’s Information Security Management System (ISMS). We have implemented robust security controls, undergone rigorous risk assessments, and continuously strive for improvement. RsNLME ensures full compliance with global data protection standards, offering peace of mind for sensitive analysis.
Learn more in our Trust Center
Schedule a RsNLME demo
Experience how RsNLME can revolutionize your pharmacometric workflows with a free one-month trial. Explore its powerful features and seamless integration with Certara’s NLME engine, designed to streamline your modeling process.
Streamline population PK/PD modeling with open-source flexibility
Access comprehensive educational resources and tutorials
Enhance efficiency with real-time configurable reports
Free Licenses for Academia: Phoenix Desktop, Pirana, and RsNLME
Certara supports education and research by offering free Pirana and RsNLME licenses for academic use, plus free Phoenix desktop licenses when teaching an academic course. Additional discounts on Phoenix solutions, training, and certification help empower students and accelerate research.
