Pharmacokinetic and Pharmacodynamic Data Analysis eBook
PK/PD Concepts and Applications
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💡 Comprehensive insights into both theory and practice of PK/PD.
🤝 Authored by distinguished experts in the field.
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Through numerous examples and over 100 tutorials, scientists learn how to apply PK/PD analysis in a variety of practical areas, from simple plasma kinetics, multi-compartment models, nonlinear kinetics, plasma protein binding, pharmacodynamic models, turnover concepts, receptor binding, functional adaptation and rebound, dose-response-time data analysis, inter-species scaling, target mediated drug disposition, and a lot more.
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eBook contents
Chapter 1:
- Basic Concepts
Chapter 2:
- Intravenous Bolus Administration
- Absorption Parameters
- Plasma and Urine Data
- Extravascular administration
- Turnover
- Nonlinear Systems
- Non-Compartmental Analysis
- Exposure
- Inter-Species Scaling
Chapter 3:
- Receptor Binding Models
- Pharmacodynamic Models
- Antagonism
- Reversible Drug Effects
- Irreversible Drug Effects
- Effect Compartment (Link) Models
- Dose-Response-Time Models
- Tolerance and Rebound Models
- Baseline Models
- Transduction Models
- Synergistic Effects
Chapter 4:
- Plot and Explore Data
- Graphical methods and linear Regression
- Assessing the Goodness-of-Fit
- F Test
- Akaike and Schwarz criteria
- Outliers
Chapter 5:
- Experimental Design
Chapter 6:
- Pattern Recognition
- Pharmacokinetic Applications
- One-compartment
- Two-compartment
- Bolus
- Toxicokinetics
- Ethanol kinetics
- Metabolite kinetics
- Nonlinear Kinetics
- Allometry
- In vitro/in vivo extrapolation
- Constant K
- Michaelis-Menten Kinetics
- r-hSOD kinetics