Model Firsts

By combining disparate data into coherent mechanistic models, quantitative systems pharmacology is becoming a key tool for picking the right dose for first-in-human trials and other early make-or-break decisions.

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Beam Me Up, Scotty! Probing the Mechanisms of Transporter-mediated Drug Disposition

Matthew Harwood

Over the last 15 years, the importance of drug transporters has become paramount for understanding drug absorption, distribution into tissues, and in particular, drug-drug interactions (DDIs). In vitro-in vivo extrapolation (IVIVE) is an approach to link in vitro systems to the human in vivo situation using algorithms and physiologically-based scaling factors. In this blog, I […]

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Topics: PBPK Modeling & Simulation

Shanghai Workshop: November 2018

Model-informed Drug Development Incorporating population variability into mechanistic prediction of PK and modeling PK/PD November 26–30 in Shanghai, China Delegates will learn how to simulate: Metabolic drug clearance (CL) Metabolic drug-drug interactions (DDIs) Gut first-pass metabolism Oral drug absorption incorporating food effects and the impact of dosage form Effect of transporters and enterohepatic recirculation on […]

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