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What’s New in the Simcyp Simulator v19?

On-Demand Webinar
Sponsors and regulatory agencies routinely use physiologically-based pharmacokinetic (PBPK) modeling and simulation to assist in dose selection and inform drug labels. Certara’s PBPK platform, the Simcyp®️ Simulator, links in vitro data to in vivo absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetic/pharmacodynamic (PK/PD) outcomes to explore potential clinical complexities prior to and during human studies and support decision-making in drug development.
Watch this webinar with Drs. Peter Kilford, Mian Zhang, and Janak Wedagedera to learn how the latest updates in the Simcyp Simulator v19, guided by the Simcyp consortium members, will support developing safer, more effective medications faster. These enhancements include:
  • Updates and Enhancements to the Simcyp Substrate and Inhibitor Libraries
  • Metabolite Back Conversion in Plasma and Tissues
  • Enhancements in Parameter Estimation and Sensitivity Analysis

About Our Speakers

Janak Wedagedera is a Senior Research Scientist at Certara UK Limited’s Simcyp Division. He received his PhD in Mathematics from University of Wales- UK and postdoctoral training from University of Warwick – UK in Systems Immunology. After serving many years in academia as a Professor in Mathematics at the University of Ruhuna – Sri Lanka,  a Visiting Professor at York University – Canada in the areas of Probability and Statistics, Disease Modelling and Systems Immunology, he joined the Simcyp team in 2013. Since then he has worked in and lead various projects in PBPK/PD Modeling, Nonlinear Optimization methods, statistical methodology, and numerical solutions via ODE solvers in a Population-PBPK context.

Peter Kilford
After receiving a BSc in Biochemistry with Toxicology, Peter completed his PhD at the University of Manchester in 2008. Peter joined the Certara, UK Simcyp Division in early 2019 to work in the science team focusing on further developments to the metabolism side of the Simcyp Simulator.

Mian Zhang is a Research Scientist at Certara UK Limited’s Simcyp Division. Mian received his PhD in DMPK from the China Pharmaceutical University. Prior to joining Simcyp, he spent his early career as a scientist in the Pharmaceutical Science Dept. at Hutchison Medi Pharma and a Senior Scientist in the DMPK Services Dept. at WuXi AppTec. Since joining Simcyp, he has led and contributed to various projects for the development and application of the Simulator for drug metabolism, transporters, and metabolite inter-conversions.

 

This webinar explained how the latest updates in the Simcyp Simulator v19, Certara’s physiologically-based pharmacokinetic (PBPK) modeling and simulation platform, will support developing safer, more effective medications faster.

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