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PAGE 2024

PAGE 2024

Satellite Workshops: PMX Analysis with R, NsLME, and Pirana Darwin

Keith Nieforth, PharmD & Mark Sale, MD

This is a full day workshop on June 25 that will introduce the student to PMX analyses in R using Certara’s R speaks NLME, Pirana, and Pirana Darwin.  By the end of the course, students will be able to create a pk model in R using the PML language, fit the model, perform diagnostics including VPC, and perform simulations.  In addition, students will be given an introduction to executing a machine learning model selection analysis using Pirana Darwin.

The workshop will include lectures and hands-on exercises. Participants will be given access to a cloud environment to perform the hands-on exercises.

A Hands-On Workshop with Simcyp Designer for Tailored PBPK-PD/QSP Models

Would you like to modify and tailor population PBPK models? This course will review the principles of PBPK modelling, using the Simcyp Simulator and how to use Simcyp Designer to modify existing PBPK models with your own extension and link them to custom-built PD/QSP models. We will have lectures to introduce the PBPK models to be changed and have hands-on exercises to train the customisation of PBPK models with the Designer. No prior knowledge is required. Access to the Simcyp Simulator and Simcyp Designer will be provided. Participant are required to bring their own laptops as the workshop is hands-on intensive.

Key aspects of the course:

  • Overview of PBPK modelling, using the Simcyp Simulator.
  • Rapidly create new models in a graphical editor – the Simcyp Designer.
  • Replace PBPK model components in Simcyp with a user-defined model.
  • Adding components/modules to simcyp PBPK models.
  • Extending PBPK models for large molecules.
  • Building PBPK driven PD/QSP models.
  • Incorporate population variability into the customized models.

COST £200+VAT Students (Coupon Code: STUDENT24) / £400+VAT Industry