PAGE 2026 – 24th Meeting

PBPK/ML

• Development and application of ML based drug renal clearance predictor — Presenting Author: Sebastian Polak

QSP AI/ML

• Active Learning with Bayesian Optimization for Efficient Virtual Population Generation using Quantitative Systems Pharmacology Models — Presenting Author: Dennis Reddyhoff

PBPK

• Applying Sampling Importance Resampling to Improve Simcyp PBPK Models Predictions Performance — Presenting Author: Celine Brochot
• Assessing Cross-Version Simcyp Simulator Prediction Performance Using a Bioequivalence Framework to Support EMA Qualification — Presenting Author: Masoud Jamei
• Integrating Endogenous Ligand Competition into a Mechanistic Whole-Body PBPK Model of Therapeutic Monoclonal Antibodies — Presenting Author: Cong Liu

Drug/Disease Modelling – Paediatrics

• Pharmacometric Analysis of Givinostat to Support Individualized Dosing Recommendations in Pediatric Patients with Duchenne Muscular Dystrophy — Presenting Author: Francesco Bellanti
• Population Pharmacokinetics of Clesrovimab in Preterm and Full-Term Infants — Presenting Author: Farina Hellmann

Drug/Disease Modelling – Oncology

• A predictive modeling framework to reconstruct and simulate PFS — Presenting Author: Mathilde Marchand
• Mechanistic modelling of CRS in T cell engagers – An application for Blinatumomab — Presenting Author: Birses Debir

Drug & Disease Modeling — Oncology & Immuno-Oncology

• Application of IO Simulator in immuno-oncology combination therapy: A small cell lung cancer case study — Presenting Author: Aiman Alam Nazki

Drug/Disease Modelling – Infection

• Population pharmacokinetic–based probability of target attainment analysis of cefepime/nacubactam and aztreonam/nacubactam for carbapenem-resistant enterobacterales infections — Presenting Author: T. Zhang
• Population pharmacokinetics, antidrug antibodies and exposure–response of VH3810109 (N6LS) in virologically suppressed adults living with HIV from the Phase 2B embrace study — Presenting Author: Thijs Zweers

Drug/Disease Modelling – Safety

• Concentration-QTc analysis of tovorafenib in patients with RAF-altered, relapsed/refractory pediatric low-grade glioma, advanced solid tumors and melanoma — Presenting Author: A. Yin Edwards

Methodology – AI/Machine Learning

• Interpretable Machine Learning-based Decision Support for Population Pharmacokinetics Diagnostics under Realistic Shrinkage and Sparsity Conditions — Presenting Author: Ana Victoria Ponce-Bobadilla
• Shaping the Future of AI/ML in Pharmacometrics through Collaboration, Education, and Best Practices — Presenting Author: Ana Victoria Ponce-Bobadilla
• Machine learning-based covariate selection in population pharmacokinetics: A systematic evaluation of Boruta algorithm with tree-based methods against SCM+ — Presenting Author: Floris Fauchet

Methodology – Study Design

• Paediatric pharmacokinetic studies could be optimized for the precision of the clinically relevant exposure endpoint instead of PK parameter precision — Presenting Author: Pyry A.J. Välitalo

Methodology – Other Topics

• Improved Numerical Stability with Phoenix NLME (QRPEM) in a Complex Sequential PK/PD Modeling Workflow — Presenting Author: Amira Ghoneim

Methodology – Model Evaluation

• Sensitivity analysis and calibration for a computationally expensive PBPK model: a case study for the PERSERIS™ in-situ forming PLGA-based implant — Presenting Author: Kevin McNally
• Bayesian Quantification of Bias and Uncertainty in Simcyp V19 Predictions of Drug-Drug Interactions — Presenting Author: Pauline Bogdanovich
• Quantitative Predictive Check (QPC): A Scalar Framework for Objective and Optimization-Ready VPC Evaluation — Presenting author: James Craig

Methodology – New Modelling Approaches

• A novel mathematical framework to predict in vivo bispecific GTX-B001 binding in skin and translation to humans — Presenting Author: Chiara Fornari
• Combining aggregate data and individual patient/subject data in model-based meta-analysis: An illustrative case study of tofacitinib in rheumatoid arthritis patients — Presenting Author: Anna Largajolli
• QPC: Predicting Human Interpretation of VPC Plots — Presenting author: Mark Sale

New Modelling Approaches

• Improving clinical data harmonization for population approaches using graph databases — Presenting Author: Luca Marzano