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Mechanistic Modeling of Genome Scale Molecular Interaction Networks

The scope of Physiologically-based Pharmacokinetic (PBPK) modeling can be expanded by assimilating mechanistic models of intracellular processes from the Systems Biology field. Genome Scale Metabolic Networks (GSMNs) represent whole sets of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are also available. Here, we introduce GSMNs and review ongoing work on integrating PBPK, GSMNs and metabolic gene regulation. We demonstrate example models.

Speaker(s): Andrzej Kierzek
Solution: PBPK Modeling & Simulation
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Speaking into the Ether: Challenges of the Virtual Pharma Workplace

In this webinar, Drs. Peter Bonate and Stacey Tannenbaum discuss what kind of technology tools can facilitate a connection with your audience and address the difficulties of speaking into the ether. They offer practical solutions that you can use to strengthen your collaboration in the virtual workplace.

Speaker(s): Peter Bonate, Stacey Tannenbaum
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Agile Access to Drug Discovery Data with D360

D360 makes it easy for all project team members to access standard discovery project data views or perform exploratory analyses. This webinar focuses on utilizing D360 to get the most out of drug discovery data by utilizing simple query-building with integrated chemistry tools and analysis tools, dynamically linked data visualizations and easy to use annotations. […]

Speaker(s): Dennis Powell
Solution: Scientific Informatics
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A New Model to Meet BioPharm Transparency Mandates and Engage Participants as Clinical Research Partners

Studies consistently show that 90% of clinical trial volunteers expect to be told the overall results of their trial. Unfortunately, most never hear anything back from the Sponsor or research center after the last study visit, leaving many volunteers wondering if their participation was valued or appreciated. Over the past five years, the nonprofit Center […]

Speaker(s): Tatyana Wanderer
Solution: Clinical Transparency & Disclosure, Regulatory & Medical Writing
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How Model-based Approaches Can Improve Precision Dosing in Clinical Care

In this webinar, Dr. Adam Darwich, Certara Lecturer in Precision Dosing at the Manchester Pharmacy School at The University of Manchester, presented several case studies that illustrate how PBPK models have been used to predict drug-drug interactions, extrapolate to special populations, and optimize clinical study design.

Speaker(s): Adam Darwich
Solution: Biosimulation, PBPK Modeling & Simulation
Therapeutic Area: Central Nervous System, Endocrinology, Infectious Disease, Oncology/Hematology, Pediatrics
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