Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
CertaraMarch 21, 2011
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
CertaraMarch 16, 2011
What is the Difference Between Individual and Population PK?
Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…
CertaraMarch 14, 2011
Blood or Plasma? Which Should You Assay for Drug Concentration?
Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…
CertaraFebruary 19, 2011
Why Should You Evaluate Dose Proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
CertaraFebruary 17, 2011
What is the Difference Between PK and TK?
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…
CertaraFebruary 15, 2011
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
CertaraFebruary 10, 2011
What are Direct and Indirect Pharmacodynamic Models?
When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…
CertaraFebruary 8, 2011
What is Modeling and Simulation?
I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…
CertaraFebruary 1, 2011
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides
Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…
CertaraFebruary 1, 2011
