Modeling and Simulation - PK/PD Archives | Page 28 of 38

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Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

When I first began learning about pharmacokinetics, I was often confused by the mean residence…

CertaraMarch 28, 2013

Publication

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…

CertaraMarch 28, 2013

Blog Knowledge Base

What is a Loading Dose?

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…

CertaraMarch 22, 2013

Knowledge Base

The Superposition Principle

Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…

CertaraMarch 14, 2013

Publication

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…

CertaraMarch 1, 2013

Publication

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

This article reports an analysis that aims to quantify the effect of fingolimod, an oral…

CertaraMarch 1, 2013

Publication

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Although smallpox has been eradicated, the United States government considers it a "material threat" and…

CertaraMarch 1, 2013

Knowledge Base

Saturable Drug Absorption

Drug absorption is the process by which a drug molecule moves from the site of…

CertaraFebruary 26, 2013

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Nonlinear PK: What Does That Mean?

You may come across a phrase like the following and wonder what it means: “……

CertaraFebruary 17, 2013

Knowledge Base

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

The maximum observed concentration (Cmax) and the time of Cmax (tmax) are both obtained directly…

CertaraFebruary 11, 2013

Modeling and Simulation – PK/PD

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

What is a Loading Dose?

The Superposition Principle

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Saturable Drug Absorption

Nonlinear PK: What Does That Mean?

Why Cmax is a Continuous Variable and Tmax is a Categorical Variable

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