Modeling and Simulation - PK/PD Archives | Page 28 of 42

Publication

A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain

Pain is a major symptom in many medical conditions which can be relieved thanks to…

CertaraFebruary 13, 2014

Publication

Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

CertaraFebruary 10, 2014

Knowledge Base

Simplifying Deconvolution

Deconvolution is used to evaluate the absorption kinetics of a drug. Unfortunately the term can…

CertaraJanuary 13, 2014

Publication

The IQ-CSRC Prospective Clinical Phase 1 Study: Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?

A collaboration between the Consortium for Innovation and Quality in Pharmaceutical Development and the Cardiac…

CertaraJanuary 1, 2014

Knowledge Base

Cassette Dosing: Advantages and Challenges

Cassette dosing is a technique primarily used in drug discovery efforts in non-clinical studies to…

CertaraDecember 16, 2013

Blog Knowledge Base

What is GLP (Good Laboratory Practice)?

Good laboratory practice or GLP is a set of principles intended to assure the quality…

CertaraDecember 9, 2013

Publication

An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment

Treprostinil diolamine (oral treprostinil) is a prostacyclin analogue under evaluation for the treatment for pulmonary…

CertaraDecember 1, 2013

Publication

Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution

In environments where complete mechanistic knowledge of the system dynamics is not available, a synergy…

CertaraDecember 1, 2013

Blog Knowledge Base

Understanding Steady State Pharmacokinetics

CertaraNovember 25, 2013

Publication

Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel

Pertuzumab is a novel antihuman epidermal growth factor receptor 2 (HER2) humanized monoclonal antibody. Combined…

CertaraNovember 24, 2013

Modeling and Simulation – PK/PD

A Model-based Meta-analysis to Compare Efficacy and Tolerability of Tramadol and Tapentadol for the Treatment of Chronic Non-malignant Pain

Clinical Population Pharmacokinetics and Toxicodynamics of Linezolid

Simplifying Deconvolution

The IQ-CSRC Prospective Clinical Phase 1 Study: Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?

Cassette Dosing: Advantages and Challenges

What is GLP (Good Laboratory Practice)?

An Evaluation of the Pharmacokinetics of Treprostinil Diethanolamine in Subjects with Hepatic Impairment

Modeling of Pharmacokinetic Systems Using Stochastic Deconvolution

Understanding Steady State Pharmacokinetics

Absence of Pharmacokinetic Drug-drug Interaction of Pertuzumab with Trastuzumab and Docetaxel

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