Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison Between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys
Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on…
CertaraFebruary 15, 2015
Calculating the Elimination Rate Constant
The elimination rate constant is the rate at which drug is cleared from the body…
CertaraFebruary 2, 2015
Population Pharmacokinetics of Ceftolozane/Tazobactam in Healthy Volunteers, Subjects with Varying Degrees of Renal Function and Patients with Bacterial Infections
Ceftolozane/tazobactam is a novel antipseudomonal cephalosporin and a β-lactamase inhibitor in clinical development for treatment…
CertaraFebruary 1, 2015
Common Misconceptions About Computer System Validation
Drug development professionals frequently use computer systems to help them understand the pharmacokinetics (PK) and…
CertaraJanuary 28, 2015
Using Modeling and Simulation to Quantify the PK of an Anti-HIV Drug for Babies
As a scientist at Certara and proud Dad to my three kids, pediatric drug development…
CertaraJanuary 15, 2015
The Effect of Plasmapheresis on Blood Pressure in Voluntary Plasma Donors
Donor plasmapheresis involves the removal of a weight-adjusted volume of plasma and the return of…
CertaraJanuary 1, 2015
Population Dose-response Analysis of Daily Seizure Count Following Vigabatrin Therapy in Adult and Pediatric Patients with Refractory Complex Partial Seizures
Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an…
CertaraJanuary 1, 2015
Pharmacokinetics of Injectable, Long-acting Nevirapine for HIV Prophylaxis in Breastfeeding Infants
Mother-to-child transmission (MTCT) of HIV-1 remains a global health problem. The World Health Organization (WHO…
CertaraJanuary 1, 2015
Onartuzumab with or without Bevacizumab in Combination with Weekly Paclitaxel Does Not Prolong QTc or Adversely Affect Other ECG Parameters in Patients with Locally Recurrent or Metastatic Triple-negative Breast Cancer
The purpose of this study was to examine the potential effect of onartuzumab, when administered…
CertaraDecember 17, 2014
