Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients Publication Population Pharmacokinetics of Intravenous Pantoprazole in Pediatric Intensive Care Patients What is already known about this subject The use of intravenous pantoprazole, a proton pump…CertaraFebruary 1, 2009
Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease Publication Intestinal Metabolism and Transport of Drugs in Children: The Effects of Age and Disease The presence of cytochrome P450 enzymes in the small bowel results in the reduced bioavailability…CertaraJuly 1, 2008
Development of CYP2D6 and CYP3A4 in the First Year of Life Publication Development of CYP2D6 and CYP3A4 in the First Year of Life Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year…CertaraMay 1, 2008
The Problems in Scaling Adult Drug Doses to Children Publication The Problems in Scaling Adult Drug Doses to Children Many drugs are unlicensed in children and consequently their doses have been scaled down from…CertaraMarch 15, 2007
Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates Publication Prediction of Clearance of Eleven Drugs and Associated Variability in Neonates Prediction of the exposure of neonates, infants and children to xenobiotics is likely to be…CertaraSeptember 1, 2006
Changes in Liver Volume from Birth to Adulthood: A Meta-analysis Publication Changes in Liver Volume from Birth to Adulthood: A Meta-analysis A diversity of equations is available for the estimation of liver volume (LV), derived from…CertaraDecember 1, 2005
Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Publication Model-based Covariate Pharmacokinetic Analysis and Lack of Cortisol Suppression by the New Inhaled Corticosteroid Ciclesonide Using a Novel Cortisol Release Model Ciclesonide is a novel and effective inhaled corticosteroid for the treatment of asthma that is…CertaraSeptember 1, 2005
Modelling Approaches to Dose Estimation in Children Publication Modelling Approaches to Dose Estimation in Children Most of the drugs on the market are originally developed for adults and dosage selection…CertaraJune 1, 2005