Development of CYP2D6 and CYP3A4 in the First Year of Life

Recently, Blake et al . ‘‘Ontogeny of dextromethorphan O- and N-demethylation in the first year of life’’ reported that CYP2D6 activity does not change with post-natal age up to 1 year. However, this conclusion, which was based on an invariant urinary dextromethorphan/dextrorphan (DM/DX) ratio over this period, is inconsistent with findings from studies in which CYP2D6 expression in liver samples was shown to increase with post-natal age.

Author(s): Trevor Johnson, Geoffrey Tucker, Amin Rostami-Hodjegan

Year: May 1, 2008