How Does the In Vivo Biliary Elimination of Drugs Change with Age? Evidence from In Vitro and Clinical Data Using a Systems Pharmacology Approach
Information on the developmental changes in biliary excretion (BE) of drugs is sparse. The aims…
CertaraJuly 1, 2016
Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio
The hepatic extraction ratio (EH) is commonly considered an "inherent attribute" of drug. It determines…
CertaraJuly 1, 2016
Does Age Affect Gastric Emptying Time? A Model-based Meta-analysis
Gastric emptying (GE) is often reported to be slower and more irregular in premature neonates than…
CertaraMay 1, 2015
Prediction of Voriconazole Non-linear Pharmacokinetics Using a Pediatric Physiologically-based Pharmacokinetic Modeling Approach
We read with interest the report by Zane and Thakker entitled ‘‘A PBPK model for…
CertaraMay 1, 2015
