Relationship Between Exposure to Sunitinib and Efficacy and Tolerability Endpoints in Patients with Cancer: Results of a Pharmacokinetic/Pharmacodynamic Meta-analysis
In this pharmacokinetic/pharmacodynamic meta-analysis, we investigated relationships between clinical endpoints and sunitinib exposure in patients…
CertaraJuly 1, 2010
Detection of Lymph Node Metastases by Gadolinium-enhanced Magnetic Resonance Imaging: Systematic Review and Meta-analysis
Gadolinium-based contrast agents are used with magnetic resonance imaging (MRI) to highlight tumor vascularity in…
CertaraFebruary 24, 2010
In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract
Mangosteen is a xanthone-containing fruit found in Southeast Asia for which health claims include maintaining healthy immune…
CertaraSeptember 1, 2009
Model-based Prediction of Phase 3 Overall Survival in Colorectal Cancer on the Basis of Phase 2 Tumor Dynamics
We developed a drug-disease simulation model to predict antitumor response and overall survival in phase…
CertaraSeptember 1, 2009
Excluding Venous Thromboembolism Using Point of Care D-dimer Tests in Outpatients: A Diagnostic Meta-analysis
This article is a review the evidence on the diagnostic accuracy of the currently available…
CertaraAugust 14, 2009
On the Use of Change in Tumor Size to Predict Survival in Clinical Oncology Studies: Toward a New Paradigm to Design and Evaluate Phase 2 Studies
Drug-independent models that link biomarker response to clinical end points are critical to support early…
CertaraAugust 1, 2009
Pharmacokinetics of Melagatran and the Effect on Ex Vivo Coagulation Time in Orthopedic Surgery Patients Receiving Subcutaneous Melagatran and Oral Ximelagatran: A Population Model Analysis
Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The…
CertaraJanuary 1, 2003
