Application of PBPK Modeling in Drug Discovery and Development at Pfizer Publication Application of PBPK Modeling in Drug Discovery and Development at Pfizer Early prediction of human pharmacokinetics (PK) and drug-drug interactions (DDI) in drug discovery and development…CertaraJanuary 1, 2012
γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters Publication γ-hydroxybutyrate Blood/Plasma Partitioning: Effect of Physiologic pH on Transport by Monocarboxylate Transporters The drug of abuse γ-hydroxybutyrate (GHB) displays nonlinear renal clearance, which has been attributed to…CertaraJanuary 1, 2012
ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis Publication ST Analysis of the Fetal Electrocardiogram in Intrapartum Fetal Monitoring: A Meta-analysis The objective of this study was to compare the effects of ST-waveform analysis in combination…CertaraJanuary 1, 2012
Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection Publication Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection The purpose of this study was to characterize exposure–response relationships of AMG 386 in a…CertaraJanuary 1, 2012
Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics Publication Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics The preclinical absorption, distribution, metabolism, and excretion (ADME) properties of Pracinostat -1H-benzimidazol-5-yl]-N-hydroxyarylamide hydrochloride; SB939], an…CertaraDecember 1, 2011
Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics Publication Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single,…CertaraDecember 1, 2011
Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans Publication Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at…CertaraDecember 1, 2011
Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis Publication Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in…CertaraDecember 1, 2011
Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond Publication Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient…CertaraDecember 1, 2011
Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Publication Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition…CertaraDecember 1, 2011