Pharmacokinetics of Oral Terbinafine in Adult Horses
The primary study objective was to compare the pharmacokinetics of p.o. terbinafine alone to p.o.…
CertaraNovember 24, 2016
Vaccination Mitigates the Impact of PRRSv Infection on the Pharmacokinetics of Ceftiofur Crystalline-free Acid in Pigs
The pharmacokinetics of intramuscularly administered ceftiofur crystalline-free acid (CCFA) were determined in pigs that were…
CertaraNovember 24, 2016
A Study to Examine the Relationship Between Metritis Severity and Depletion of Oxytetracycline in Plasma and Milk after Intrauterine Infusion
Metritis is a frequent problem in postpartum dairy cows. Intrauterine therapy with the antimicrobial oxytetracycline…
CertaraOctober 1, 2016
Phase 1 Study Assessing the Pharmacokinetic Profile and Safety of Avibactam in Patients with Renal Impairment
Avibactam is a non-β-lactam β-lactamase inhibitor intended for use as a fixed-dose combination with ceftazidime…
CertaraJuly 12, 2016
A Tutorial on Pharmacodynamic Scripting Facility in Simcyp
The Simcyp® Simulator provides a framework for mechanistic Physiologically-Based Pharmacokinetic/Pharmacodynamic modelling of potentially interacting drugs.…
CertaraJuly 9, 2016
More Power to OATP1B1: An Evaluation of Sample Size in Pharmacogenetic Studies Using a Rosuvastatin PBPK Model for Intestinal, Hepatic, and Renal Transporter-mediated Clearances
Rosuvastatin is a substrate of choice in clinical studies of organic anion-transporting polypeptide (OATP)1B1- and…
CertaraJuly 1, 2016
Short-term Efficacy Reliably Predicts Long-term Clinical Benefit in Rheumatoid Arthritis Clinical Trials as Demonstrated by Model-based Meta-analysis
The objective of this study was to assess the relationship between short-term and long-term treatment…
CertaraJuly 1, 2016
Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics
Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients…
CertaraJuly 1, 2016
