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What does the Clinical Pharmacology Plan for a Biologic Look Like?

Monoclonal antibodies are now widely used in the treatment of several diseases, providing effective and…

CertaraAugust 6, 2021

Publication

Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals

Find out how body‑weight and sex effects on DEC PK in filariasis patients, supporting improved…

CertaraJuly 26, 2021

Blog

Key considerations to ensure maximal probability of antibody drug conjugate development success

Antibody drug conjugates (ADC) are a unique way to obliterate tumor cells and represent an…

CertaraJuly 8, 2021

Publication

Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis

Learn how cystatin‑C improves vancomycin clearance prediction in PICS patients, reducing variability and preventing supratherapeutic…

CertaraMarch 16, 2021

Publication

Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients

Explore how key covariates and showed higher‑frequency dosing improves linezolid target attainment in critically ill…

CertaraFebruary 8, 2021

Blog

8 tips for successfully developing oligonucleotide therapies

By Eva Gil Berglund and Nathalie H Gosselin Oligonucleotide therapeutics are a validated class of…

CertaraFebruary 1, 2021

White Paper

“Where do I start?”: Strategies for selecting the first dose for human clinical trials

This guide to dose selection for first-in-human studies explains the conceptual framework, methods, and tools…

CertaraDecember 22, 2020

Publication

Metformin Treatment of Type 2 Diabetes Mellitus in Pregnancy: Update on Safety and Efficacy

CertaraApril 25, 2018

Blog

Using a pharmacology to payer framework to support product development

Modeling and simulation (M&S) of complex systems has primarily advanced vertically in differing scientific domains…

CertaraMarch 16, 2018

Publication

Cost-utility Analysis of Antiviral Use Under Pandemic Influenza Using a Novel Approach—Linking Pharmacology, Epidemiology and Heath Economics

CertaraMarch 1, 2018

Clinical Pharmacology

What does the Clinical Pharmacology Plan for a Biologic Look Like?

Population Pharmacokinetics of Diethylcarbamazine in Patients with Lymphatic Filariasis and Healthy Individuals

Key considerations to ensure maximal probability of antibody drug conjugate development success

Cystatin C and/or creatinine-based estimated glomerular filtration rate for prediction of vancomycin clearance in long-stay critically ill patients with persistent inflammation, immunosuppression and catabolism syndrome (PICS): a population pharmacokinetics analysis

Population Pharmacokinetics and Dosage Optimization of Linezolid in Critically Ill Pediatric Patients

8 tips for successfully developing oligonucleotide therapies

“Where do I start?”: Strategies for selecting the first dose for human clinical trials

Metformin Treatment of Type 2 Diabetes Mellitus in Pregnancy: Update on Safety and Efficacy

Using a pharmacology to payer framework to support product development

Cost-utility Analysis of Antiviral Use Under Pandemic Influenza Using a Novel Approach—Linking Pharmacology, Epidemiology and Heath Economics

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