Publication

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

Discover how major CYP2C19 genotype effects on voriconazole PK, supporting genotype‑guided dose adjustments to avoid…

CertaraJanuary 3, 2022

Publication

The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers

See how rifampicin reduces fuzuloparib exposure by up to 90%, confirming a major CYP3A4 induction…

CertaraDecember 26, 2021

Publication

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma

Find out how lower vinorelbine exposure in children and strong BSA effects, supporting dose refinement…

CertaraDecember 13, 2021

Publication

Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections

Learn how adjusted‑body‑weight dosing optimises polymyxin B exposure in obese patients, avoiding toxicity while achieving…

CertaraNovember 22, 2021

On-Demand Webinar

Predicting and Taming Immunogenicity: Strategies for your Biologic Drug

Immunogenicity is the ability of a foreign substance, such as a drug or vaccine, to…

CertaraNovember 19, 2021

Case Study

Dose Optimization Using Population PK for an Orphan Drug

RAPALIMUS® Tablets (sirolimus) is Nobelpharma’s orphan drug developed from an oral medication that is sold…

CertaraNovember 17, 2021

Publication

A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats

Explore how altered PK of fenugreek bioactives in diabetic rats, with faster absorption and slower…

CertaraNovember 16, 2021

Publication

Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects

Discover how bioequivalence of generic and branded budesonide nasal sprays, with matched PK and strong…

CertaraNovember 16, 2021

Blog

A day in the life of a clinical pharmacology consultant

Strategic consulting within drug discovery and development is an exciting career choice for many. Unlike…

CertaraOctober 8, 2021

Publication

Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients

See how standard vancomycin dosing is insufficient for pediatric liver‑transplant patients, requiring higher or more…

CertaraOctober 6, 2021

Clinical Pharmacology

Application of Population Pharmacokinetic Analysis to Characterize CYP2C19 Mediated Metabolic Mechanism of Voriconazole and Support Dose Optimization

The impact of rifampicin on the pharmacokinetics of fuzuloparib in healthy Chinese male volunteers

Pharmacokinetics of oral vinorelbine in French children with recurrent or progressive primary low-grade glioma

Population Pharmacokinetics of Polymyxin B in Obese Patients for Resistant Gram-Negative Infections

Predicting and Taming Immunogenicity: Strategies for your Biologic Drug

Dose Optimization Using Population PK for an Orphan Drug

A novel UPLC-MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats

Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects

A day in the life of a clinical pharmacology consultant

Population Pharmacokinetics and Dosing Optimization of Vancomycin in Pediatric Liver Transplant Recipients

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