Publication

Comparative Bioequivalence and Food Effect of Two Formulations of 30-mg Nifedipine Controlled-Release Tablets in Healthy Chinese Adults

Explore how nifedipine CR formulations are bioequivalent; food reduces exposure modestly, analysed using Phoenix WinNonlin.

CertaraMarch 13, 2024

Publication

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

Discover how PopPK modelling supports dose‑adjustment considerations for ORIN1001 based on bilirubin and lean body…

CertaraMarch 4, 2024

Blog

Dose optimization considerations for targeted radiation therapies

The acquisitions of targeted radiation therapy companies (TRT) Point Biopharma by Eli Lilly and RayzeBio…

CertaraFebruary 16, 2024

Publication

Pharmacokinetic – toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin – induced Peripheral Neurpathu

See how DRG‑based PK‑TD modelling predicts neuropathy severity and supports safer oxaliplatin dosing strategies using…

CertaraFebruary 1, 2024

Publication

Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis

Learn how both regimens achieve PK/PD targets; fixed‑dose regimen recommended with trough monitoring, modelled using…

CertaraJanuary 30, 2024

Publication

The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model

Find out how PK‑PD modelling shows delayed lipid‑lowering effects driven by key flavonoids in Wendan…

CertaraJanuary 23, 2024

Publication

Population Pharmacokinetics and Individualized Medication of Azithromycin for Injection in Children Under 6 Years Old

Explore how weight and age drive azithromycin PK variability; PopPK modelling supports personalized dosing using…

CertaraJanuary 20, 2024

Publication

Population pharmacokinetics of rotigotine extended‑release microspheres for intramuscular injection in early‑stage Parkinson’s disease

Discover how body weight meaningfully affects rotigotine ER exposure; race has minimal impact, modelled using…

CertaraJanuary 17, 2024

Publication

Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects

See how high‑fat meals reduce valsartan exposure by over 50% while amlodipine PK is unaffected,…

CertaraJanuary 11, 2024

Publication

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China

Learn how the first Chinese PopPK model shows weight, sex, and ulcer status influence ilaprazole…

CertaraJanuary 10, 2024

Clinical Pharmacology

Comparative Bioequivalence and Food Effect of Two Formulations of 30-mg Nifedipine Controlled-Release Tablets in Healthy Chinese Adults

Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors

Dose optimization considerations for targeted radiation therapies

Pharmacokinetic – toxicodynamic Modeling to Elucidate the Involvement of Dorsal Root Ganglion Neuron in Oxaliplatin – induced Peripheral Neurpathu

Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis

The in vivo study on antioxidant activity of wendan decoction in treating hyperlipidemia: a pharmacokinetic-pharmacodynamic (PK-PD) model

Population Pharmacokinetics and Individualized Medication of Azithromycin for Injection in Children Under 6 Years Old

Population pharmacokinetics of rotigotine extended‑release microspheres for intramuscular injection in early‑stage Parkinson’s disease

Effect of High-Fat Meal on the Pharmacokinetics and Safety of Valsartan/Amlodipine Fixed Dose Combination Tablets in Healthy Subjects

Population pharmacokinetic modeling of ilaprazole in healthy subjects and patients with duodenal ulcer in China

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