Publication: Journal of Pharmaceutical Sciences
Abstract
Pharmacokinetic data for injectable azithromycin in young children remain limited despite its common clinical use. This prospective study enrolled children under six years old receiving injectable azithromycin, using 254 plasma concentrations from 148 patients to build a population pharmacokinetic model with Phoenix NLME. Body weight and age were identified as the key covariates influencing azithromycin clearance and volume of distribution, and Monte Carlo simulation was used to derive a simple, practical individualized dosing scheme. This validated model and dosing scheme are intended to support more personalized azithromycin therapy in young pediatric patients.
Author(s): Zhang Y, Wang Y, Li J, Wang H, Hou M, Dong R, Li X
Published: January 20, 2024
Phoenix NLME: A Simple Dosing Scheme for Young Children
Phoenix NLME’s population model and simulation produced a practical, weight-and-age-based azithromycin dosing scheme for children under six in this study. Within a Phoenix platform built on more than 30 years of PK/PD expertise, Phoenix NLME can be paired with Model Designer to select, configure, and simulate models directly in the browser, guided by an AI assistant.
