Central Nervous System (CNS) Archives

Publication

Recombinantly expressed CYP450 systems (rCYPs) are often used to screen for irreversible/quasi-irreversible enzyme inhibitors during…

CertaraSeptember 1, 2007

Publication

The objectives of these analyses were to (1) develop a population pharmacokinetic/pharmacodynamic model for a…

CertaraMarch 1, 2007

Publication

The aim of this study was to model the in vivo kinetic consequences of mechanism-based…

CertaraNovember 1, 2006

Publication

A predictive population pharmacokinetic model was developed for a novel cyclooxygenase-2 (COX-2) inhibitor CS-706, using…

CertaraMay 1, 2006

Publication

The aim of this study was to develop a pain relief model for a cyclooxygenase…

CertaraApril 1, 2006

Publication

A novel model-based meta-analysis was used to quantify the dose-response relationship of sumatriptan and eletriptan…

CertaraSeptember 1, 2005

Publication

Pregabalin is being evaluated for the treatment of neuropathic pain. Two phase 2 studies were…

CertaraNovember 1, 2003

Central Nervous System (CNS)