Advancing pharmacometrics in Africa – Transition from capacity development toward job creation Publication Advancing pharmacometrics in Africa – Transition from capacity development toward job creation This CPT article showcases, the Applied Pharmacometrics Training (APT) program, launched in 2021 by Pharmacometrics…CertaraDecember 9, 2024
A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population Publication A Sequential Population Pharmacokinetic Model of Zilovertamab Vedotin in Patients with Hematologic Malignancies Extrapolated to the Pediatric Population CertaraNovember 7, 2024
Semi-mechanistic Model of ATG-101, a PD-L1/4-1BB Bispecific Antibody, for Treatment of Solid Tumors Poster Semi-mechanistic Model of ATG-101, a PD-L1/4-1BB Bispecific Antibody, for Treatment of Solid Tumors Abstract Trimer formation is key to the pharmacology of the bispecific ATG-101 but is difficult…CertaraSeptember 16, 2024
Blinatumomab Trimer Formation Poster Blinatumomab Trimer Formation Insights from a Mechanistic PKPD Model on the Implications for Switching from Infusion to Subcutaneous…CertaraSeptember 16, 2024
Dose Selection for DuoBody®-PD-L1x4-1BB (GEN1046) Poster Dose Selection for DuoBody®-PD-L1x4-1BB (GEN1046) Abstract DuoBody®-PD-L1x4-1BB (GEN1046) is an investigational, first-in-class, bispecific antibody designed to elicit an antitumor immune…CertaraSeptember 9, 2024
Optimizing Avidity of Bispecific Drugs Poster Optimizing Avidity of Bispecific Drugs Abstract Bispecific drugs have great potential to improve tissue selectivity through avid binding interactions but…CertaraSeptember 9, 2024
Effects of Tissue Targeting Bispecifics on Therapeutic Window Poster Effects of Tissue Targeting Bispecifics on Therapeutic Window Abstract Objectives: The presence of target receptors in non-target tissues can reduce the therapeutic window…CertaraSeptember 9, 2024
Optimizing Clinical Development: Saving Time and Costs Case Study Optimizing Clinical Development: Saving Time and Costs Strategic mechanistic modeling solutions help an immunoncology biotech accelerate their clinical development of novel therapeutics.CertaraAugust 16, 2024
Application of Quantitative Systems Pharmacology to guide the optimal dosing of COVID-19 vaccines Publication Application of Quantitative Systems Pharmacology to guide the optimal dosing of COVID-19 vaccines Optimal use and distribution of coronavirus disease 2019 (COVID-19) vaccines involves adjustments of dosing. Due…CertaraJuly 31, 2021
Maximizing Oligonucleotide Therapeutic Development: How They Work Blog Maximizing Oligonucleotide Therapeutic Development: How They Work This is the first of three blog posts discussing best practices for developing oligonucleotides. Interest…CertaraMay 7, 2021