Simcyp Animal is a whole-body physiologically-based pharmacokinetic (PBPK) modeling platform for rat, dog, and knock-out mouse. It is based on the Simcyp Simulator with simplified interfaces and well-validated models.
Simulations with Simcyp Animal can help identify key data requirements and inform the design of subsequent experiments. It can also increase confidence in in vitro-in vivo extrapolation (IVIVE) before moving to human simulations. Simcyp Animal can be used to:
- Assess PK properties
- Evaluate formulation and food effects on drug absorption
- Predict concentration-time profiles in plasma, tissues and organs
- Investigate the formation and kinetics of primary metabolites
- Increased accuracy: When used with the Simcyp Simulator, Simcyp Animal allows comparison of human and animal data without relying upon allometric scaling
- Save time: Compound import and batch processing capabilities allow large numbers of compounds to be screened quickly and sensitivity analysis to be performed
- Satisfy ethical imperatives: Simcyp Animal helps fulfill the ethical obligation towards the refinement, replacement and reduction of in vivo studies in animals
- Save money: The knock-out mouse simulator allows you to investigate how adding or removing specific genes controlling drug metabolizing enzymes and transporters affects the ADME properties of a drug
- Study oral drug absorption and physiological differences in the dog gut wall with a unique mechanistic permeability (mech Peff) model
- Evaluate inter-subject physiological variability in dogs
- Validate implemented models and compare the properties of their new drugs with these reference compounds with databases of commonly used compounds
- Access transparent algorithms, methods, and visual outputs through graphical interfaces
Our 5-year CRADA with the FDA’s Center for Veterinary Medicine, aims to streamline veterinary drug product development and evaluation with to PBPK dog models.
This collaboration investigates the effect of extrinsic and intrinsic factors in combination or independently on drug kinetics, such as effect of drug formulation and food on drug exposure in animals.
This facilitates using pharmacokinetic principles to address questions associated with designing and interpreting animal safety studies and clinical field studies and enable integrating model predictions with data from safety and effectiveness studies to develop product labels.