Simcyp Animal is a state-of-the-art, whole-body PBPK/PD modeling platform that empowers researchers to translate and predict drug behavior across preclinical species. Built on the trusted Simcyp Simulator, this platform offers simplified interfaces and well-validated models. Simulations with Simcyp Animal can help identify key data requirements, refine in vitro-in vivo extrapolation (IVIVE), and inform the design of subsequent experiments.
Simcyp™ Animal
PBPK/PD modeling platform to streamline preclinical and veterinary drug research for rats, dogs, monkeys, and mice
Learn more about Simcyp Animal
Model and verify preclinical species data to confirm assumptions prior to making first-in-human (FIH) predictions.
Predict dose for desired plasma and tissue concentration-time profiles for animals and humans.
Simulate drug exposure for various formulations and administration routes.
Evaluate the effect of food on oral drug absorption and pharmacokinetics.
Cooperative Research and Development Agreement (CRADA) with the FDA's Center for Veterinary Medicine
Beginning in 2012, Certara’s CRADA with the FDA’s Center for Veterinary Medicine aims to utilize the Simcyp Dog Simulator to streamline veterinary drug product development and evaluation to improve the safety and efficacy of veterinary drugs for canines. In 2024, our CRADA was extended to focus research and development on a canine brain model.
"A defect in the permeability-limiting glycoprotein (P-gp) that leads to an inactive protein is very frequent in Collie breed, Longhaired Whippet, and Shetland Sheepdog. This Mdr1-delition can cause toxicities not seen in other species. Because of the involvement of functional P-gp at the blood brain barrier, the brain has always been of particular importance. Therefore, to understand how concentrations of drugs in Collies may be associated with the observed brain toxicity (or toxicities in other organs), we need to make sure that we have that organ described in our model. "
Sibylle Neuhoff, PhD
Senior Scientific Advisor & Transporters Lead at Certara
Key features of Simcyp Animal
Simcyp Animal offers unparalleled capabilities for modeling preclinical species and in vitro data to confirm assumptions prior to human predictions. By leveraging mechanistic models, researchers can evaluate interspecies differences, predict drug behavior, and refine study designs.
Simulate exposure across different formulations and routes of administration.
Evaluate differences in oral drug absorption due to physiological differences across species gut wall.
Evaluate inter-subject PK/PD variability arising due to physiological variability in dogs and monkeys.
Predict pharmacokinetics (PK) and pharmacodynamics (PD) using virtual genetically modified models.
Translation between species, accounting for physiology and anatomy differences and differences in metabolizing enzymes and transporters and plasma protein levels between preclinical species and humans.
Benefits of Simcyp Animal
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Schedule a demo to see how Simcyp Animal can transform your preclinical research.
Translate and predict drug behavior across species with confidence.
Refine IVIVE and streamline experiment design.
Align with ethical research practices using advanced in silico modeling.
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Simcyp Animal FAQs
What species does Simcyp Animal support?
Simcyp Animal supports rats, dogs, monkeys, and mice.
How does Simcyp Animal align with ethical research practices?
Simcyp Animal adheres to the 3Rs principles, reducing reliance on animal studies.
Can Simcyp Animal predict human PK/PD?
Yes, Simcyp Animal enables human PK/PD predictions using animal PBPK/PD extrapolation.
