Past Event
Date
December 15-18, 2024
Location
San Diego, CA
Antibody Engineering & Therapeutics
We are excited to be presenting at this conference
December 15th at 3:15pm
Bridging the in vitro to in vivo Gap for T-cell Engagers Using QSP Modeling
David Flowers, PhD, Director at Certara
The unique cell-to-cell crosslinking action of T-cell engagers (TCEs) poses challenges for in vitro to in vivo translation. Recent advances in QSP models of TCEs capture key biophysical details of crosslinking, enabling rational techniques for first-in-human dose selection and efficacious dose prediction from in vitro potency assays and preclinical animal studies. This talk will review these developments and explain how QSP models can support and accelerate TCE development.