Pharmacokinetics, lymph node uptake and mechanistic PK model of near infrared dye labeled bevacizumab after IV and SC administration in mice

Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibodybevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration inmice. Fluorescence imaging and enzyme-linked immunosorbent assay (ELISA) assays were developed and validated to measure the concentration of bevacizumab in plasma.

Fang Wu, Mitalee Tamhane, Marilyn E. Morris
June 1, 2012
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