γ-hydroxybutyrate (GHB) -induced respiratory depression: Combined receptor-transporter inhibition therapy for treatment in GHB overdose

Overdose of & γ;-hydroxybutyrate (GHB) frequently causes respiratory depression, occasionally resulting in death; however, little is known about the dose-response relationship or effects of potential overdose treatment strategies on GHB-inducedrespiratory depression. In these studies, the parameters of respiratory rate, tidal volume, and minute volume were measured using whole-body plethysmography in rats administered GHB.

 

Bridget L. Morse, Nisha Vijay, Marilyn E. Morris
August 1, 2012
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