Antibody-Drug Conjugate (ADC) Model Pack
Antibody-Drug Conjugate (ADC) Model Pack
What’s Included?
Applied BioMath Assess™ ADC Model Pack includes 42 models covering monospecific and bispecific ADCs with and without avidity.
- Monospecific ADC Model Pack
- Monospecific ADC: One-compartment model of a bivalent ADC binding to membrane receptor and competing against soluble ligand
- Monospecific ADC (4-compartment): Four-compartment model of a bivalent ADC binding to membrane receptor and competing against soluble ligand
- Monospecific ADC with Membrane Ligand Competitor: One-compartment model of a bivalent ADC binding to membrane receptor and competing against membrane ligand
- Monospecific ADC with Membrane Ligand Competitor (4-compartment): Four-compartment model of a bivalent ADC binding to membrane receptor and competing against membrane ligand
- In Vitro Monospecific ADC: One-compartment in vitro model of a bivalent ADC binding to membrane receptor and competing against soluble ligand
- In Vitro Monospecific ADC with Membrane Ligand Competitor: One-compartment in vitro model of a bivalent ADC binding to membrane receptor and competing against membrane ligand
- Bispecific ADC Model Pack
- Bispecific ADC
- Bispecific ADC (4-compartment)
- Bispecific ADC Anti-Ligand
- Bispecific ADC Anti-Ligand (4-compartment)
- Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor
- Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor (4-compartment)
- Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor
- Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor (4-compartment)
- Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor
- Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor (4-compartment)
- In Vitro Bispecific ADC
- In Vitro Bispecific ADC Anti-Ligand
- In Vitro Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor
- In Vitro Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor
- In Vitro Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor
- Avid Monospecific ADC Model Pack
- Monospecific ADC with Avidity (4-compartment)
- Monospecific ADC with Membrane Ligand Competitor with Avidity (4-compartment)
- In Vitro Monospecific ADC with Avidity
- In Vitro Monospecific ADC with Membrane Ligand Competitor with Avidity
- Monospecific ADC with Avidity
- Monospecific ADC with Membrane Ligand Competitor with Avidity
- Avid Bispecific ADC Model Pack
- Bispecific ADC with Avidity (4-compartment)
- Bispecific ADC Anti-Ligand with Avidity (4-compartment)
- Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor with Avidity (4-compartment)
- Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor with Avidity (4-compartment)
- Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor with Avidity (4-compartment)
- In Vitro Bispecific ADC with Avidity
- In Vitro Bispecific ADC Anti-Ligand with Avidity
- In Vitro Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor with Avidity
- In Vitro Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor with Avidity
- In Vitro Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor with Avidity
- Bispecific ADC with Avidity
- Bispecific ADC Anti-Ligand with Avidity
- Bispecific ADC Anti-Ligand with Receptor x Membrane Ligand Competitor with Avidity
- Bispecific ADC with Membrane Ligand x Soluble Ligand Competitor with Avidity
- Bispecific ADC with Membrane Ligand x Membrane Ligand Competitor with Avidity
Model Resources
Each model in the ADC Model Pack includes a mechanism of action diagram and a pharmacology diagram (Fig 1) with model parameters and their nominal values (next Fig/table).
Figure 1: Model Diagrams
Figure 2: Model Parameters
Each model in Applied BioMath Assess™ has a unique set of parameters, many of which are listed below, based on the model pharmacology and number of compartments. This list is not exhaustive. In the app, each parameter contains a default value based on expansive literature searches and references.
Additional Model Packs
18 models covering 9 common pharmacologies.
Models for solid tumors, in-vitro experiments, and solid tumors with 2 cell types.
8 models covering LNP-encapsulated mRNA and siRNA therapies
Models covering both soluble and membrane ligand pharmacologies.
4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.
Antibody-Drug Conjugate (ADC) Model Pack
Complete the form to receive your copy of the Antibody-Drug Conjugate (ADC) Model Pack overview.
Support
On-Demand Support
Have any questions about Applied BioMath Assess or interested in seeing a demo? We have software engineers ready to chat!
Contact us today at abm-support@certara.com.
Documentation
Visit our Applied BioMath Assess documentation portal for product documentation as well as video case studies.