Protein Degrader Model Pack
Protein Degrader Model Pack
What’s Included?
Applied BioMath Assess™ Protein Degrader Model Pack includes 4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.
- PROTAC degrading an intracellular protein in vitro (beta)
- An in vitro model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vitro (beta)
- An in vitro model of a molecular glue degrader targeting and degrading intracellular proteins
- PROTAC degrading an intracellular protein in vivo (beta)
- An in vivo model of a PROTAC targeting and degrading intracellular proteins
- MGD degrading an intracellular protein in vivo (beta)
- An in vivo model of a molecular glue degrader targeting and degrading intracellular proteins
Insights on Molecular Glue Degraders
Hear from Josh Apgar, PhD, VP, QSP Software and Products at Certara as he discusses how modeling approaches can help address the challenges of molecular glue drug development.
Model Resources
Each model in the Protein Degrader Pack includes a pharmacology diagram (Figure 1) with model parameters and their nominal values (Figure 2).
Figure 1: Model Diagrams
Figure 2: Model Parameters
Each model in Applied BioMath Assess™ Protein Degrader Model Pack has a unique set of parameters, a sample of which is shown here, based on the model pharmacology and number of compartments. More details on the full list of parameters are available upon request. In the app, each parameter contains a default value based on expansive literature searches and references.
Webinar
Guiding Target and Lead Optimization for a Molecular Glue Degrader
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Protein Degrader Model Pack
Complete the form to receive your copy of the Protein Degrader Model Pack overview.
Support
On-Demand Support
Have any questions about Applied BioMath Assess or interested in seeing a demo? We have software engineers ready to chat!
Contact us today at abm-support@certara.com.
Documentation
Visit our Applied BioMath Assess documentation portal for product documentation as well as video case studies.