Gene Therapy Model Pack
Gene Therapy Model Pack
What’s Included?
Applied BioMath Assess™ Gene Therapy Model Pack includes 8 models covering LNP-encapsulated mRNA and siRNA therapies.
- LNP-encapsulated mRNA expressing an intracellular protein in vitro
- Two-compartment model of mRNA uptake, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an intracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP-encapsulated mRNA expressing an extracellular protein in vitro
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an extracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP- encapsulated siRNA expressing an intracellular protein in vitro
- LNP-encapsulated siRNA expressing an intracellular protein in vivo
- LNP-encapsulated siRNA expressing an extracellular protein in vitro
- LNP-encapsulated siRNA expressing an extracellular protein in vivo
Model Resources
Each model in the Gene Therapy Model Pack includes a pharmacology diagram (Figure 1) with model parameters and their nominal values (Figure 2).
Figure 1: Model Diagrams
Figure 2: Model Parameters
Each model in Applied BioMath Assess™ Gene Therapy Model Pack has a unique set of parameters, a sample of which is shown here, based on the model pharmacology and number of compartments. More details on the full list of parameters are available upon request. In the app, each parameter contains a default value based on expansive literature searches and references.
Webinar
Applications of a QSP Model of LNP mRNA Delivery for the Treatment of Crigler-Najjar Syndrome Type 1
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Gene Therapy Model Pack
Complete the form to receive your copy of the Gene Therapy Model Pack overview.
Support
On-Demand Support
Have any questions about Applied BioMath Assess or interested in seeing a demo? We have software engineers ready to chat!
Contact us today at abm-support@certara.com.
Documentation
Visit our Applied BioMath Assess documentation portal for product documentation as well as video case studies.