The Cell Engager Model Pack offers a comprehensive suite of models to enhance your oncology research. This pre-built model pack is used with Assess™, and each model is meticulously crafted to simulate the pharmacological interactions of biotherapeutics, providing insights into therapeutic index (TI) and dose tolerability. By integrating these models into your research, you can predict therapeutic outcomes, optimize biotherapeutic designs, and evaluate risks such as on-target, off-tumor toxicities.
Cell Engager Model Pack
Pre-built library of validated QSP models for solid tumor research
QSP Models for Cell Engagers
Cell Engager for Solid Tumors: A four-compartment model linking T cell receptors (TCR) to tumor-associated antigens (TAA) on tumor and normal cells.
Tumor Cell Engager for In-Vitro Experiments: Models TCR interactions with TAA in controlled experimental environments.
Effector Cell Engager for Multi-Cell Tumors: Simulates biotherapeutics engaging effector cell receptors (ECR) across two effector cell types.
Model diagrams and parameters
Each model in the Cell Engager Model Pack includes a mechanism of action diagram and a pharmacology diagram with model parameters and their nominal values. Each model in Assess™ has a unique set of parameters, based on the model pharmacology and number of compartments. In the app, each parameter contains a default value based on expansive literature searches and references.
Created in Biorender
Explore other Assess™ QSP model packs
In addition to the Cell Engager model pack, Assess™ offers several libraries of monospecific and bispecific, single-compartment and multicompartment models covering common pharmacologies.
Download the Cell Engager model pack
Discover how the Cell Engager Model Pack can transform your oncology research.
Gain early insights into therapeutic index and dose tolerability
Optimize biotherapeutic designs with predictive modeling
Access comprehensive resources for streamlined research
On-demand support
Have any questions about AssessTM model packs? We have software engineers ready to chat!
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Documentation
Visit our AssessTM documentation portal for product documentation as well as video case studies.
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