What is Pharmacokinetics?
You might think this is a simple question, especially for an expert in pharmacokinetics. Well,…
CertaraMay 16, 2010
Population Pharmacokinetic/Pharmacodynamic Model for a C.E.R.A. in Both ESA-naive and ESA-treated Chronic Kidney Disease Patients with Renal Anemia
This study aimed to develop a population pharmacokinetic/pharmacodynamic (PK/PD) model for C.E.R.A., a continuous erythropoietin…
CertaraMay 1, 2010
Physiologically-based Mechanistic Modeling to Predict Complex Drug–drug Interactions Involving Simultaneous Competitive and Time-dependent Enzyme Inhibition by Parent Compound and Its Metabolite in Both Liver and Gut—The Effect of Diltiazem on the Time-course of Exposure to Triazolam
The aim of this study was to predict the magnitude of metabolic drug-drug interaction (mDDI)…
CertaraMarch 18, 2010
Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism Using a Population-based Simulator
We identify here for the first time the low-affinity cytochrome P450 (P450) isoforms that metabolize…
CertaraMarch 1, 2010
Under-reporting of Venous and Arterial Thrombotic Events in Randomized Clinical Trials: A Meta-analysis
For the detection of unwanted outcomes of new interventions, physicians rely on adverse event reporting.…
CertaraMarch 1, 2010
A Semi-mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance
Liver cirrhosis is characterized by a decrease in functional hepatocytes, lowered circulating levels of plasma…
CertaraMarch 1, 2010
Detection of Lymph Node Metastases by Gadolinium-enhanced Magnetic Resonance Imaging: Systematic Review and Meta-analysis
Gadolinium-based contrast agents are used with magnetic resonance imaging (MRI) to highlight tumor vascularity in…
CertaraFebruary 24, 2010
The Use of Biosimulation in the Design of a Novel Multilevel Weight Loss Maintenance Program for Overweight Children
Weight loss outcomes achieved through conventional behavior change interventions are prone to deterioration over time.…
CertaraFebruary 18, 2010
Prediction of Vss from In Vitro Tissue Binding Studies
To predict volume of distribution at steady-state (Vss), empirical (e.g., allometry) and mechanistic (using physicochemical…
CertaraJanuary 1, 2010
Population Pharmacokinetics of Teduglutide Following Repeated Subcutaneous Administrations in Healthy Participants and in Patients with Short Bowel Syndrome and Crohn’s Disease
Teduglutide is a GLP-2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's…
CertaraJanuary 1, 2010
