Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection Publication Exposure-response Relationship of AMG 386 in Combination with Weekly Paclitaxel in Recurrent Ovarian Cancer and Its Implication for Dose Selection The purpose of this study was to characterize exposure–response relationships of AMG 386 in a…CertaraJanuary 1, 2012
Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics Publication Pre-clinical Metabolism and Disposition of SB939 (Pracinostat), an Orally Active Histone Deacetylase Inhibitor, and Prediction of Human Pharmacokinetics The preclinical absorption, distribution, metabolism, and excretion (ADME) properties of Pracinostat -1H-benzimidazol-5-yl]-N-hydroxyarylamide hydrochloride; SB939], an…CertaraDecember 1, 2011
Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics Publication Influence of Mild and Moderate Hepatic Impairment on Axitinib Pharmacokinetics To evaluate the effects of hepatic impairment on the pharmacokinetics and safety of a single,…CertaraDecember 1, 2011
Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans Publication Effect of Microgravity on the Pharmacokinetics of Ibuprofen in Humans The pharmacokinetics of ibuprofen were studied under microgravity (µG) conditions and compared with those at…CertaraDecember 1, 2011
Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis Publication Population Pharmacokinetic-pharmacodynamic-disease Progression Model for Effects of Anakinra in Lewis Rats with Collagen-induced Arthritis A population pharmacokinetic-pharmacodynamic-disease progression (PK/PD/DIS) model was developed to characterize the effects of anakinra in…CertaraDecember 1, 2011
Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond Publication Model-based Meta-analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond High development cost, low development success, cost-disciplined health-care policies, and intense competition demand an efficient…CertaraDecember 1, 2011
Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Publication Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose-response Meta-analysis Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition…CertaraDecember 1, 2011
A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis Publication A Dose-response Meta-analysis for Quantifying Relative Efficacy of Biologics in Rheumatoid Arthritis We present a dose-response meta-analysis to quantify relative efficacy of biologic disease-modifying antirheumatic drugs (DMARDs)…CertaraDecember 1, 2011
Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance Publication Application of a Systems Approach to the Bottom-up Assessment of Pharmacokinetics in Obese Patients: Expected Variations in Clearance The maintenance dose of a drug is dependent on drug clearance, and thus any biochemical…CertaraDecember 1, 2011
Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies Publication Reducing Systems Biology to Practice in Pharmaceutical Company Research: Selected Case Studies Reviews of the productivity of the pharmaceutical industry have concluded that the current business model…CertaraNovember 18, 2011