Adding a Placebo Component to Your PK/PD Model in Phoenix
PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…
CertaraAugust 20, 2014
Lack of Angiopoietin-like-2 Expression Limits the Metabolic Stress Induced by a High-fat Diet and Maintains Endothelial Function in Mice
Angiopoietin-like-2 (angptl2) is produced by several cell types including endothelial cells, adipocytes and macrophages, and…
CertaraAugust 15, 2014
Bioanalytical Calibration Curves
At the request of a reader, I have decided to extend my series on bioanalysis…
CertaraAugust 12, 2014
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival
Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…
CertaraAugust 1, 2014
Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information
We aimed to investigate the application of combined mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) modeling…
CertaraAugust 1, 2014
Radiometric Analysis
One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…
CertaraJuly 29, 2014
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
CertaraJuly 14, 2014
Simulation of Monoclonal Antibody Pharmacokinetics in Humans Using a Minimal Physiologically-based Model
Compared to small chemical molecules, antibodies and Fc-containing derivatives (mAbs) have unique pharmacokinetic behavior characterized by…
CertaraJuly 9, 2014
