pre-update Archives

Blog

Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland

Officially, Prof. Malcolm Rowland has retired. This scientific pioneer has been helping lay the foundation…

CertaraFebruary 23, 2016

On-Demand Webinar

How LC-MS Proteomics Is Revolutionizing PBPK Modeling and Simulation

Drug-metabolizing enzymes and drug transporters play an important role in hepatic drug metabolism and disposition…

CertaraFebruary 18, 2016

Blog

How Modeling and Simulation Can Bring New Immuno-oncology Treatments to Patients

Immuno-oncology, which harnesses the patient's own immune system to fight cancer, is one of the…

CertaraFebruary 16, 2016

Blog

Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?

An IVIVC (in vitro-in vivo correlation) is a mathematical relationship that predicts key pharmacokinetic parameters…

CertaraFebruary 9, 2016

Publication

Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning

The objective of this study was to investigate the effects of carprofen administered immediately before…

CertaraFebruary 1, 2016

Publication

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

CertaraFebruary 1, 2016

Publication

Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

In vitro-in vivo extrapolation of clearance, embedded in a clinical trial simulation, was used to…

CertaraFebruary 1, 2016

Publication

Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy

CertaraJanuary 5, 2016

Publication

Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield

Previous research has shown that postpartum administration of the nonsteroidal antiinflammatory drug (NSAID) sodium salicylate…

CertaraJanuary 1, 2016

Publication

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

Mastitis is a frequent problem among dairy cows, reducing milk yield and increasing cull rates.…

CertaraJanuary 1, 2016

pre-update

Inside the Mind of Pharmacometrics Pioneer, Professor Malcolm Rowland

How LC-MS Proteomics Is Revolutionizing PBPK Modeling and Simulation

How Modeling and Simulation Can Bring New Immuno-oncology Treatments to Patients

Conventional & Mechanistic IVIVC: Complementary or Clashing Methods?

Impact of Carprofen Administration on Stress and Nociception Responses of Calves to Cautery Dehorning

Factors Influencing the Central Nervous System Distribution of a Novel Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GSK2126458: Implications for Overcoming Resistance with Combination Therapy for Melanoma Brain Metastases

Incorporating In Vitro Information on Drug Metabolism into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphisms on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application

Short Communication Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are Associated with p16 INK4a Expression in Subjects on Combination Therapy

Hot Topic: Early Postpartum Treatment of Commercial Dairy Cows with Nonsteroidal Antiinflammatory Drugs Increases Whole-lactation Milk Yield

Altered Plasma Pharmacokinetics of Ceftiofur Hydrochloride in Cows Affected with Severe Clinical Mastitis

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