Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics Publication Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients…CertaraJuly 1, 2016
Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio Publication Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio The hepatic extraction ratio (EH) is commonly considered an "inherent attribute" of drug. It determines…CertaraJuly 1, 2016
Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process Publication Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process CertaraJune 16, 2016
Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment Publication Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication…CertaraJune 11, 2016
Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs Publication Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs CertaraJune 1, 2016
Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves Publication Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves OBJECTIVE To describe plasma pharmacokinetic parameters and tissue elimination of flunixin in veal calves. ANIMALS…CertaraJune 1, 2016
Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data Publication Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…CertaraJune 1, 2016
Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions Publication Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions CertaraJune 1, 2016
Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses Publication Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses The pharmacokinetics and safety of ceftolozane, a novel cephalosporin, and tazobactam, a β-lactamase inhibitor, alone…CertaraJune 1, 2016
Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions Publication Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and…CertaraJune 1, 2016