pre-update Archives

Publication

Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics

Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients…

CertaraJuly 1, 2016

Publication

Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio

The hepatic extraction ratio (EH) is commonly considered an "inherent attribute" of drug. It determines…

CertaraJuly 1, 2016

Publication

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

CertaraJune 16, 2016

Publication

Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment

Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication…

CertaraJune 11, 2016

Publication

Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs

CertaraJune 1, 2016

Publication

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

OBJECTIVE To describe plasma pharmacokinetic parameters and tissue elimination of flunixin in veal calves. ANIMALS…

CertaraJune 1, 2016

Publication

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…

CertaraJune 1, 2016

Publication

Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions

CertaraJune 1, 2016

Publication

Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses

The pharmacokinetics and safety of ceftolozane, a novel cephalosporin, and tazobactam, a β-lactamase inhibitor, alone…

CertaraJune 1, 2016

Publication

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and…

CertaraJune 1, 2016

pre-update

Potential Sources of Inter-subject Variability in Monoclonal Antibody Pharmacokinetics

Considering Age Variation When Coining Drugs as High Versus Low Hepatic Extraction Ratio

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment

Lessons Learned: Dose Selection of Small Molecule-targeted Oncology Drugs

Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves

Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data

Metformin and Cimetidine: Physiologically-based Pharmacokinetic Modeling to Investigate Transporter Mediated Drug–drug Interactions

Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Healthy Adult Subjects Following Single and Multiple Ascending Doses

Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions

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