Why are PK Parameters Lognormally Distributed? Knowledge Base Why are PK Parameters Lognormally Distributed? The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…CertaraFebruary 10, 2011
What are Direct and Indirect Pharmacodynamic Models? Knowledge Base What are Direct and Indirect Pharmacodynamic Models? When constructing pharmacodynamic (PD) models, you will often encounter the adjectives “direct” and “indirect” describing…CertaraFebruary 8, 2011
What is Modeling and Simulation? Knowledge Base What is Modeling and Simulation? I am currently attending a short conference on modeling and simulation in pediatric clinical pharmacology,…CertaraFebruary 1, 2011
Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Publication Immediate Consequences of Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides Polycyclic aromatic hydrocarbons (PAH) are among the likely major causative agents for lung cancer in…CertaraFebruary 1, 2011
Relationship Between AUC and Volume of Distribution Knowledge Base Relationship Between AUC and Volume of Distribution A few days ago on the pharmacokinetics listserve PharmPK, the following question appeared: I’m having…CertaraJanuary 26, 2011
Where Did the 80-125% Bioequivalence Criteria Come From? BlogKnowledge Base Where Did the 80-125% Bioequivalence Criteria Come From? Most people involved in clinical pharmacokinetics are familiar with the 80-125% criterion. This criterion is…CertaraJanuary 24, 2011
Generics and Bioequivalence Knowledge Base Generics and Bioequivalence As the debate about health care in the United States continues forward, the term “generic…CertaraJanuary 10, 2011
What are Compartmental Models? Knowledge Base What are Compartmental Models? Learn about compartmental models and their importance in pharmacokinetics. Find out how they simplify drug…CertaraJanuary 5, 2011
What are Drug-drug Interactions Anyway? Knowledge Base What are Drug-drug Interactions Anyway? A current buzz phrase in pharmaceutical research right now is “drug-drug interaction” or simply “drug…CertaraJanuary 5, 2011
The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain Publication The Role of the Breast Cancer Resistance Protein (ABCG2) in the Distribution of Sorafenib to the Brain ATP-binding cassette transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) have been shown to…CertaraJanuary 1, 2011