What to Do with Those BLQs!
BLQ values are like those pimples we used to get as teenagers. They…
CertaraApril 6, 2011
The Difference Between Vd and Vss
There are many terms used to represent volume of distribution, but two common ones are…
CertaraMarch 31, 2011
What is Shrinkage?
In 2007, Mats Karlsson and Radojka Savic published a perspective in Clinical Pharmacology & Therapeutics…
CertaraMarch 29, 2011
Is a Monte Carlo Simulation an Exotic Drink?
The term “Monte Carlo simulation” is often used in the modeling and simulation literature with…
CertaraMarch 21, 2011
What is WinNonlin?
A reader suggested that I write a similar post about WinNonlin. Great idea! Thank you!…
CertaraMarch 16, 2011
What is the Difference Between Individual and Population PK?
Pharmacokinetic analysis is often broken into two areas … “PK” and “population PK”. Sometimes the…
CertaraMarch 14, 2011
Blood or Plasma? Which Should You Assay for Drug Concentration?
Explore blood vs. plasma drug concentration assays. Learn their differences, relationships, and impact on accurate…
CertaraFebruary 19, 2011
Why Should You Evaluate Dose Proportionality?
Dose proportionality is a common phrase used pharmacokinetics. Early in the pre-clinical development process, we…
CertaraFebruary 17, 2011
What is the Difference Between PK and TK?
Explore the key differences between pharmacokinetics (PK) and toxicokinetics (TK), their roles in drug development,…
CertaraFebruary 15, 2011
Why are PK Parameters Lognormally Distributed?
The statistical analysis of pharmacokinetic parameters is often overlooked and not always well understood. The…
CertaraFebruary 10, 2011
