What is Hysteresis in PK/PD Analysis?
I apologize to all my readers for such a long lapse between posts. After a…
CertaraOctober 26, 2011
Safety and Population Pharmacokinetic Analysis of Intravenous Acetaminophen in Neonates, Infants, Children, and Adolescents with Pain or Fever
The administration of acetaminophen via the oral and rectal routes may be contraindicated in specific…
CertaraOctober 16, 2011
Pharmacokinetics of SN2310, an Injectable Emulsion that Incorporates a New Derivative of SN-38 in Patients with Advanced Solid Tumors
SN2310 is an injectable emulsion composed of vitamin E, a succinate derivative, as well as…
CertaraOctober 1, 2011
Ammonia Control in Children with Urea Cycle Disorders (UCDs); Phase 2 Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate
Twenty four hour ammonia profiles and correlates of drug effect were examined in a phase…
CertaraAugust 1, 2011
How Can PK/PD Analysis Add Value to Patient Care?
In May 2011, T.J. Smith and B.E. Hillner published an opinion piece in the New…
CertaraJuly 11, 2011
What is Curve Stripping?
The process of curve stripping is used in both compartmental and non-compartmental analysis. Each pharmacokinetic…
CertaraJuly 6, 2011
Pharmacokinetic-pharmacodynamic Disease Progression Model for Effect of Etanercept in Lewis Rats with Collagen-induced Arthritis
The purpose of this study was to develop a pharmacokinetic-pharmacodynamic disease progression (PK/PD/DIS) model to…
CertaraJuly 1, 2011
Clinical Tolerance and Toxicity of Intravenous Baclofen: A Pilot Study in a Canine Model
Assess safety and tolerance of intravenous (IV) baclofen using a dog model. Prospective pharmacokinetic study…
CertaraJuly 1, 2011
Model-based Development of Anacetrapib, a Novel Cholesteryl Ester Transfer Protein Inhibitor
A model-based strategy was used to inform the early clinical development of anacetrapib, a novel…
CertaraJune 1, 2011
Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-experienced and CCR5 Antagonist-naive Patients
TBR-652 is a novel CCR5 antagonist with potent in vitro anti-HIV activity. The objective of…
CertaraApril 12, 2011
