Modeling and Simulation - PK/PD Archives | Page 27 of 38

Publication

Model-based Drug Development in Oncology: What’s Next?

Model-based estimates of tumor growth inhibition (TGI) metrics have the potential to enhance learning in…

CertaraApril 1, 2013

Publication

Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide

CS-8635, a fixed-dose triple combination of olmesartan, amlodipine, and hydrochlorothiazide, was developed to address the…

CertaraApril 1, 2013

Blog Knowledge Base

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

When I first began learning about pharmacokinetics, I was often confused by the mean residence…

CertaraMarch 28, 2013

Publication

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

Axitinib is a potent and selective inhibitor of vascular endothelial growth factor receptors 1, 2,…

CertaraMarch 28, 2013

Blog Knowledge Base

What is a Loading Dose?

Drug therapy in chronic disease situations requires systemic drug levels to reach target steady-state levels…

CertaraMarch 22, 2013

Knowledge Base

The Superposition Principle

Discover the superposition principle and its significance in science and mathematics. Learn how this fundamental…

CertaraMarch 14, 2013

Publication

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Cerebral white matter (WM) injury and stroke are common neuropathological injuries in newborns with congenital…

CertaraMarch 1, 2013

Publication

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

This article reports an analysis that aims to quantify the effect of fingolimod, an oral…

CertaraMarch 1, 2013

Publication

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Although smallpox has been eradicated, the United States government considers it a "material threat" and…

CertaraMarch 1, 2013

Knowledge Base

Saturable Drug Absorption

Drug absorption is the process by which a drug molecule moves from the site of…

CertaraFebruary 26, 2013

Modeling and Simulation – PK/PD

Model-based Drug Development in Oncology: What’s Next?

Model-supported Development of CS-8635: A Fixed-dose Combination of Olmesartan, Amlodipine, and Hydrochlorothiazide

Mean Residence Time (MRT): Understanding How Long Drug Molecules Stay in the Body

Axitinib in Metastatic Renal Cell Carcinoma: Results of a Pharmacokinetic and Pharmacodynamic Analysis

What is a Loading Dose?

The Superposition Principle

Plasma Topiramate Concentrations from Doses Associated with Neuroprotection Against White Matter Injury and Stroke in Two Strains of Rat Pups

Estimating Time to Disease Progression Comparing Transition Models and Survival Methods—An Analysis of Multiple Sclerosis Data

Pharmacokinetic and Pharmacodynamic Modeling to Determine the Human Dose of ST-246(R) to Protect Against Smallpox

Saturable Drug Absorption

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