Adding a Placebo Component to Your PK/PD Model in Phoenix
PK/PD modeling is an exciting are of research in clinical pharmacology. Most often we try…
CertaraAugust 20, 2014
Bioanalytical Calibration Curves
At the request of a reader, I have decided to extend my series on bioanalysis…
CertaraAugust 12, 2014
Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival
Modeling and simulation is proposed to support drug development phase transitions in oncology. Longitudinal tumor-size…
CertaraAugust 1, 2014
Radiometric Analysis
One of the oldest methods used for the quantitation of drug molecules is radiometric analysis.…
CertaraJuly 29, 2014
Understanding LC/MS/MS
The most common bioanalytical method in use today is LC/MS/MS, or liquid chromatography (LC) tandem…
CertaraJuly 15, 2014
Population Pharmacokinetic Analysis of Dutogliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor
Dutogliptin is a selective dipeptidyl peptidase-4 inhibitor shown to be efficacious and safe in patients…
CertaraJuly 14, 2014
Application of a Physiologically-based Pharmacokinetic Model to Predict OATP1B1-related Variability in Pharmacodynamics of Rosuvastatin
Typically, pharmacokinetic-pharmacodynamic (PK/PD) models use plasma concentration as the input that drives the PD model. However, interindividual variability in…
CertaraJuly 9, 2014
What is HPLC/UV?
In my series about bioanalysis for the pharmacokineticist, I thought I would start with the…
CertaraJuly 8, 2014
Population Pharmacokinetics and Bayesian Estimation of Tacrolimus Exposure in Pediatric Liver Transplant Recipients
Objectives of this study were to develop a population pharmacokinetic (PopPK) model for tacrolimus in…
CertaraJune 1, 2014
