Model Informed Drug Development Archives

Publication

Mechanism-based Population Modeling of the Effects of Vildagliptin on GLP-1, Glucose, and Insulin in Patients with Type 2 Diabetes

The aim of this study was to build a mechanism-based population pharmacodynamic model to describe…

CertaraMarch 1, 2012

Publication

Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites

The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an…

CertaraMarch 1, 2012

Publication

Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay!

Physiologically based pharmacokinetic (PBPK) modeling is an extremely useful approach with the ability to predict…

CertaraMarch 1, 2012

Publication

Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir

This study examined drug interactions between buprenorphine, a partial opioid agonist used for opioid dependence…

CertaraFebruary 1, 2012

Publication

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

To determine the effect of dose, the anatomical site of injection, and the injection volume…

CertaraFebruary 1, 2012

Publication

Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

VEGF-C156S is a recombinant form of human vascular endothelial growth factor C (VEGF-C), which targets…

CertaraFebruary 1, 2012

Publication

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1,…

CertaraFebruary 1, 2012

Publication

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Objective: Taspine, isolated from Radix et Rhizoma Leonticis has demosntrated potential proctiective effects against cancer.…

CertaraJanuary 1, 2012

Publication

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Roux-en-Y gastric bypass (RYGB) is the most frequent bariatric procedure performed in the United States,…

CertaraJanuary 1, 2012

Publication

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

Clopidogrel is an antiplatelet agent widely used in cardiovascular diseases and an inactive prodrug that…

CertaraJanuary 1, 2012

Model Informed Drug Development

Mechanism-based Population Modeling of the Effects of Vildagliptin on GLP-1, Glucose, and Insulin in Patients with Type 2 Diabetes

Population Pharmacokinetic Model for a Novel Oral Hypoglycemic Formed In Vivo: Comparing the Use of Active Metabolite Data Alone Versus Using Data of Upstream and Downstream Metabolites

Physiologically-based Pharmacokinetic (PBPK) Modeling: It is Here to Stay!

Interactions Between Buprenorphine and the Protease Inhibitors Darunavir-ritonavir and Fosamprenavir-ritonavir

Subcutaneous Absorption of Monoclonal Antibodies: Role of Dose, Site of Injection, and Injection Volume on Rituximab Pharmacokinetics in Rats

Influence of Route of Administration and Liposomal Encapsulation on Blood and Lymph Node Exposure to the Protein VEGF-C156S

Effect of Ketoconazole on the Pharmacokinetics of Axitinib in Healthy Volunteers

Tas13D Inhibits Growth of SMMC-7721 Cell via Suppression VEGF and EGF Expression

Preliminary Comparison of Sertraline Levels in Postbariatric Surgery Patients Versus Matched Non-surgical Cohort

Effects of Omeprazole and Genetic Polymorphism of CYP2C19 on the Clopidogrel Active Metabolite

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