Pharmacokinetic Profile of Defibrotide in Patients with Renal Impairment
Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable, potentially life-threatening complication…
CertaraJune 11, 2016
Pharmacokinetics and Tissue Elimination of Funixin in Veal Calves
OBJECTIVE To describe plasma pharmacokinetic parameters and tissue elimination of flunixin in veal calves. ANIMALS…
CertaraJune 1, 2016
Development of a Permeability-limited Model of the Human Brain and Cerebrospinal Fluid (CSF) to Integrate Known Physiological and Biological Knowledge: Estimating Time Varying CSF Drug Concentrations and Their Variability Using In Vitro Data
A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal…
CertaraJune 1, 2016
Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions
In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and…
CertaraJune 1, 2016
Can QSP Save Lives? Lessons from the Bial Trial Debacle
One of the biggest challenges for the pharmaceutical industry is the high rate of drug…
CertaraMay 4, 2016
Optimization of Vancomycin Dosing Regimens to Achieve Therapeutic Targets in Critically Ill Patients in Thailand
It is essential to rapidly achieve therapeutic vancomycin concentrations in critically ill patients with gram-positive…
CertaraMay 1, 2016
A Six-stage Workflow for Robust Application of Systems Pharmacology
Quantitative and systems pharmacology (QSP) is increasingly being applied in pharmaceutical research and development. One…
CertaraMay 1, 2016
Academic Licenses
Simcyp grants academic licenses for the Simcyp Simulator to centers of excellence in research related…
CertaraApril 27, 2016
